ArticleScientific reports2015
Associations between serum 25-hydroxyvitamin D and bone turnover markers in a population based sample of German children.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Bone turnover in arginine vasopressin deficiency: a comparative study with primary polydipsia and healthy controls.The Journal of clinical endocrinology and metabolism · 2026Trial
- Classification of Vitamin D Status Based on Vitamin D Metabolism: A Randomized Controlled Trial in Hypertensive Patients.Nutrients · 2024Trial
- Bone turnover in pregnancy, measured by urinary CTX, is influenced by vitamin D supplementation and is associated with maternal bone health: findings from the Maternal Vitamin D Osteoporosis Study (MAVIDOS) trial.The American journal of clinical nutrition · 2021Trial
- Blood heavy metal levels and bone turnover markers in Korean elementary school children.Central European journal of public health · 2026Article
- Circulating Total Osteocalcin Reflects Bone Mineral Physiology Rather than Metabolic Risk in Pediatric Obesity.Nutrients · 2026Article
- Evaluation of Osteonecrosis Risk Using Serum C-Terminal Cross-Linked Telopeptide of Type 1 Collagen (CTX-1) Levels in Osteoporotic Patients: Effects of Drug Holidays and Risk Factors.The Eurasian journal of medicine · 2026Article
- Association of bone turnover C-terminal telopeptide levels, 25-hydroxyvitamin D concentrations and calcium intake in Malaysian adolescents.Frontiers in nutrition · 2025Article
- Reference Intervals (RIs) of the Bone Turnover Markers (BTMs) in Children and Adolescents: A Proposal for Effective Use.Biomedicines · 2024Article
- The vitamin D status in a Chinese osteogenesis imperfecta population and its correlation with bone metabolic markers and bone density.Frontiers in nutrition · 2024Article
- Variation of Bone Turnover Markers in Childhood and Adolescence.International journal of clinical practice · 2023Article
- [Serum vitamin KZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- Broad application prospects of bone turnover markers in pediatrics.Journal of clinical laboratory analysis · 2022Review
- Bone markers and bone mineral density associates with periodontitis in females with poly-cystic ovarian syndrome.Journal of bone and mineral metabolism · 2022Article
- Serum and Urinary Osteocalcin in Healthy 7- to 19-Year-Old Finnish Children and Adolescents.Frontiers in pediatrics · 2021Article
- The importance of maternal pregnancy vitamin D for offspring bone health: learnings from the MAVIDOS trial.Therapeutic advances in musculoskeletal disease · 2021Review
- Physical Determinants of Vitamin D Photosynthesis: A Review.JBMR plus · 2021Article
- Effect of Vitamin D Levels on Bone Remodeling in Healthy Women.International journal of endocrinology and metabolism · 2020Article
- The Associations of Vitamin D Status with Athletic Performance and Blood-borne Markers in Adolescent Athletes: A Cross-Sectional Study.International journal of environmental research and public health · 2019Article
- The Paradoxical Role of Uric Acid in Osteoporosis.Nutrients · 2019Review
- The Role of Nutrients in Reducing the Risk for Noncommunicable Diseases during Aging.Nutrients · 2019Review
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe vitamin D deficiency is known to cause rickets, however epidemiological studies and RCTs did not reveal conclusive associations for other parameters of bone health. In our study, we aimed to investigate the association between serum levels of 25(OH) vitamin D and bone turnover markers in a population-based sample of children. 25(OH)D, calcium (Ca), osteocalcin (OC), and β-Crosslaps (β-CTx) were measured in 2798 ten-year-old children from the German birth cohorts GINIplus and LISAplus. Linear regression was used to determine the association between bone turnover markers and 25(OH)D levels. 25(OH)D, OC, and β-CTx showed a clear seasonal variation. A 10 nmol/l increase in 25(OH)D was significantly associated with a 10.5 ng/l decrease (p < 0.001) in β-CTx after adjustment for design, sex, fasting status, time of blood drawn, BMI, growth rate, and detectable testosterone/estradiol. For OC alone no significant association with 25(OH)D was observed, whereas the β-CTx-to-OC ratio was inversely associated with 25(OH)D (-1.7% change, p < 0.001). When stratifying the analyses by serum calcium levels, associations were stronger in children with Ca levels below the median. This study in school-aged children showed a seasonal variation of 25(OH)D and the bone turnover markers OC and β-CTx. Furthermore a negative association between 25(OH)D and the bone resorption marker β-CTx was observed.
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