ReviewGenes, brain, and behavior2016
Modeling neurodevelopmental cognitive deficits in tasks with cross-species translational validity.
Review in Genes, brain, and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Residual Effects of Acute and Subchronic Zolpidem Treatments on Attentional Processes in Aged Female Rats.Fundamental & clinical pharmacology · 2026Article
- Maximising translational value of the Iowa gambling task in preclinical studies through the use of the rodent touchscreen.Frontiers in psychiatry · 2025Review
- Article
- Postnatal Phencyclidine-Induced Deficits in Decision Making Are Ameliorated by Optogenetic Inhibition of Ventromedial Orbitofrontal Cortical Glutamate Neurons.Biological psychiatry global open science · 2024Article
- Developmental Manipulation-Induced Changes in Cognitive Functioning.Current topics in behavioral neurosciences · 2023Article
- The schizophrenia risk gene Map2k7 regulates responding in a novel contingency-shifting rodent touchscreen gambling task.Disease models & mechanisms · 2022Article
- Developmental emergence of persistent memory for contextual and auditory fear in mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- The Free-movement pattern Y-maze: A cross-species measure of working memory and executive function.Behavior research methods · 2021Article
- From the Clinic to the Laboratory, and Back Again: Investigations on Cannabinoids and Endocannabinoid System Modulators for Treating Schizophrenia.Frontiers in psychiatry · 2021Review
- The relevance of a rodent cohort in the Consortium on Individual Development.Developmental cognitive neuroscience · 2020Article
- Neurobehavioural complications of sleep deprivation: Shedding light on the emerging role of neuroactive steroids.Journal of neuroendocrinology · 2020Review
- Oxytocin improves probabilistic reversal learning but not effortful motivation in Brown Norway rats.Neuropharmacology · 2019Article
- Potentials and Pitfalls of Cross-Translational Models of Cognitive Impairment.Frontiers in behavioral neuroscience · 2019Review
- Psychoactive drug exposure during breastfeeding: a critical need for preclinical behavioral testing.Psychopharmacology · 2018Review
- Reverse translated and gold standard continuous performance tests predict global cognitive performance in schizophrenia.Translational psychiatry · 2018Article
- Relationship between effortful motivation and neurocognition in schizophrenia.Schizophrenia research · 2018Article
- Cholinergic Mechanisms of Target Oddball Stimuli Detection: The Late "P300-Like" Event-Related Potential in Rats.Neural plasticity · 2018Article
- Gene × Environment Interaction in Developmental Disorders: Where Do We Stand and What's Next?Frontiers in psychology · 2018Article
- The 5 choice continuous performance test (5C-CPT): A novel tool to assess cognitive control across species.Journal of neuroscience methods · 2017Review
- Animal models for bipolar disorder: from bedside to the cage.International journal of bipolar disorders · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Numerous psychiatric disorders whose cognitive dysfunction links to functional outcome have neurodevelopmental origins including schizophrenia, autism and bipolar disorder. Treatments are needed for these cognitive deficits, which require development using animal models. Models of neurodevelopmental disorders are as varied and diverse as the disorders themselves, recreating some but not all aspects of the disorder. This variety may in part underlie why purported procognitive treatments translated from these models have failed to restore functioning in the targeted patient populations. Further complications arise from environmental factors used in these models that can contribute to numerous disorders, perhaps only impacting specific domains, while diagnostic boundaries define individual disorders, limiting translational efficacy. The Research Domain Criteria project seeks to 'develop new ways to classify mental disorders based on behavioral dimensions and neurobiological measures' in hopes of facilitating translational research by remaining agnostic toward diagnostic borders derived from clinical presentation in humans. Models could therefore recreate biosignatures of cognitive dysfunction irrespective of disease state. This review highlights work within the field of neurodevelopmental models of psychiatric disorders tested in cross-species translational cognitive paradigms that directly inform this newly developing research strategy. By expounding on this approach, the hopes are that a fuller understanding of each model may be attainable in terms of the cognitive profile elicited by each manipulation. Hence, conclusions may begin to be drawn on the nature of cognitive neuropathology on neurodevelopmental and other disorders, increasing the chances of procognitive treatment development for individuals affected in specific cognitive domains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.