Evidence map›Paper›PMID 26667316›Full record

ArticleThe Journal of infectious diseases2016

Microscopic Plasmodium falciparum Gametocytemia and Infectivity to Mosquitoes in Cambodia.

Jessica T Lin, Ratawan Ubalee, Chanthap Lon, Sujata Balasubramanian, Worachet Kuntawunginn, Rifat Rahman, Piyaporn Saingam, Thay Kheang Heng, Dav Vy, Savoeun San and 13 more

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Global patterns of submicroscopicThe Lancet. Microbe · 2021
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  20. Gametocyte Carriage, Antimalarial Use, and Drug Resistance in Cambodia, 2008-2014.The American journal of tropical medicine and hygiene · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Jessica T LinDivision of Infectious Diseases, University of North Carolina School of Medicine.
Ratawan UbaleeDepartments of Entomology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Chanthap LonArmed Forces Research Institute of Medical Sciences.
Sujata BalasubramanianDivision of Infectious Diseases, University of North Carolina School of Medicine.
Worachet KuntawunginnImmunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Rifat RahmanDivision of Infectious Diseases, University of North Carolina School of Medicine.
Piyaporn SaingamImmunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Thay Kheang HengNational Malaria Center, Phnom Penh.
Dav VyRoyal Cambodian Armed Forces, Phnom Penh.
Savoeun SanBattambang Referral Hospital, Cambodia.
Sarath NuomArmed Forces Research Institute of Medical Sciences.
Hana BurklyImmunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Nitima ChanaratImmunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Chanudom PonsaDepartments of Entomology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Lauren LevitzDepartment of Epidemiology, Gillings School of Global Public Health.
Christian ParobekCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill.
Char Meng ChuorNational Malaria Center, Phnom Penh.
Sok SomethyRoyal Cambodian Armed Forces, Phnom Penh.
Michele SpringImmunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Charlotte LanteriImmunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Panita GosiImmunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Steven R MeshnickDepartment of Epidemiology, Gillings School of Global Public Health.
David L SaundersImmunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.

Funding

Genetic determinants of Plasmodium vivax relapseK08AI110651 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIN, JESSICA · 2014 to 2018
$869k
Investigating the targets and strain specificity of antibodies against P. vivaxF30AI109979 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PAROBEK, CHRISTIAN · 2015 to 2017
$108k
NIAID NIH HHS F30 AI109979NIAID NIH HHS K08 AI110651
6 · The paper itself

Abstract

Although gametocytes are essential for malaria transmission, in Africa many falciparum-infected persons without smear-detectable gametocytes still infect mosquitoes. To see whether the same is true in Southeast Asia, we determined the infectiousness of 119 falciparum-infected Cambodian adults to Anopheles dirus mosquitoes by membrane feeding. Just 5.9% of subjects infected mosquitoes. The 8.4% of patients with smear-detectable gametocytes were >20 times more likely to infect mosquitoes than those without and were the source of 96% of all mosquito infections. In low-transmission settings, targeting transmission-blocking interventions to those with microscopic gametocytemia may have an outsized effect on malaria control and elimination.

Indexed as

AdolescentAdultAgedAnimalsAnophelesFemaleHumansInsect VectorsMalaria, FalciparumMiddle AgedParasite LoadParasitemiaPlasmodium falciparumYoung AdultAnopheles dirusgametocyteinfectious reservoirmalaria transmissionmembrane feedingPlasmodium falciparumsubmicroscopic

Identifiers

PMID26667316
PMCPMC4813737

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.