ArticleBrain : a journal of neurology2016
Neuroeconomic dissociation of semantic dementia and behavioural variant frontotemporal dementia.
Article in Brain : a journal of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 60 citations in OpenAlex.
- A large-scale dataset of choice and response-time data in intertemporal choice.Scientific data · 2026Article
- Mapping the brain atrophy mediating increased impatience for reward in frontotemporal dementia.Communications biology · 2026Article
- A structural MRI marker predicts individual differences in impulsivity and classifies patients with behavioral-variant frontotemporal dementia from matched controls.bioRxiv : the preprint server for biology · 2024Article
- Positive autobiographical memory recall does not influence temporal discounting: an internal meta-analysis of experimental studies.Journal Of Economic Psychology · 2024Article
- The guaranteed euros: Probabilistic discounting in behavioural-variant frontotemporal dementia.Journal of neuropsychology · 2024Article
- Reward processing deficits arise early in familial frontotemporal dementia.Frontiers in neuroscience · 2024Article
- Inappropriate trusting behaviour in dementia.Frontiers in neurology · 2024Article
- Real World Financial Mismanagement in Alzheimer's Disease, Frontotemporal Dementia, and Primary Progressive Aphasia.Journal of Alzheimer's disease : JAD · 2024Article
- "Ten euros now" temporal discounting in Huntington disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Social and non-social working memory in neurodegeneration.Neurobiology of disease · 2023Article
- "Bitcoin now": temporal discounting in Bitcoin holders.Frontiers in neuroscience · 2023Article
- Neuroanatomical and cellular degeneration associated with a social disorder characterized by new ritualistic belief systems in a TDP-C patient vs. a Pick patient.Frontiers in neurology · 2023Article
- The architecture of abnormal reward behaviour in dementia: multimodal hedonic phenotypes and brain substrate.Brain communications · 2023Article
- RISK aversion in Italian forensic and non-forensic patients with schizophrenia spectrum disorders.PloS one · 2023Article
- Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseases.Brain : a journal of neurology · 2022Article
- Subjective Time in Dementia: A Critical Review.Brain sciences · 2021Review
- Interoception Primes Emotional Processing: Multimodal Evidence from Neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Neural and behavioral correlates of episodic memory are associated with temporal discounting in older adults.Neuropsychologia · 2020Article
- Interactions between decision-making and emotion in behavioral-variant frontotemporal dementia and Alzheimer's disease.Social cognitive and affective neuroscience · 2020Article
- Links between autobiographical memory richness and temporal discounting in older adults.Scientific reports · 2020Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Many neuropsychiatric disorders are marked by abnormal behaviour and decision-making, but prevailing diagnostic criteria for such behaviours are typically qualitative and often ambiguous. Behavioural variant frontotemporal dementia and semantic variant primary progressive aphasia (also called semantic dementia) are two clinical variants of frontotemporal dementia with overlapping but distinct anatomical substrates known to cause profound changes in decision-making. We investigated whether abnormal decision-making in these syndromes could be more precisely characterized in terms of dissociable abnormalities in patients' subjective evaluations of valence (positive versus negative outcome) and of time (present versus future outcome). We presented 28 patients with behavioural variant frontotemporal dementia, 14 patients with semantic variant primary progressive aphasia, 25 patients with Alzheimer's disease (as disease controls), and 61 healthy older control subjects with experimental tasks assaying loss aversion and delay discounting. In general linear models controlling for age, gender, education and Mini-Mental State Examination score, patients with behavioural variant frontotemporal dementia were less averse to losses than control subjects (P < 0.001), while patients with semantic variant primary progressive aphasia discounted delayed rewards more steeply than controls (P = 0.019). There was no relationship between loss aversion and delay discounting across the sample, nor in any of the subgroups. These findings suggest that abnormal behaviours in neurodegenerative disease may result from the disruption of either of two dissociable neural processes for evaluating the outcomes of action. More broadly, these findings suggest a role for computational methods to supplement traditional qualitative characterizations in the differential diagnosis of neuropsychiatric disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.