ReviewPediatric nephrology (Berlin, Germany)2016
Prognostic factors and biomarkers of congenital obstructive nephropathy.
Review in Pediatric nephrology (Berlin, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Is BMP-7 a promising diagnostic and prognostic biomarker for pediatric obstructive uropathy?BMC urology · 2026Observational
- Nadir creatinine as a predictor of renal outcomes in PUVs: A systematic review and meta-analysis.Frontiers in pediatrics · 2023Review
- Early detection of ureteropelvic junction obstruction in neonates with prenatal diagnosis of renal pelvis dilatation usingScientific reports · 2022Article
- Quantitative renal magnetic resonance imaging: magnetic resonance urography.Pediatric radiology · 2022Review
- Serum and urine periostin and cytokeratin-18 in children with congenital obstructive nephropathy.Central-European journal of immunology · 2022Article
- The Usefulness of Urinary Periostin, Cytokeratin-18, and Endoglin for Diagnosing Renal Fibrosis in Children with Congenital Obstructive Nephropathy.Journal of clinical medicine · 2021Article
- Diminished Systemic Amino Acids Metabolome and Lipid Peroxidation in Ureteropelvic Junction Obstruction (UPJO) Infants Requiring Surgery.Journal of clinical medicine · 2021Article
- Comparing predictive values of carbohydrate antigen 19-9, neutrophil gelatinase-associated lipocalin, and kidney injury molecule-1 in 161 patients with ureteropelvic junction obstruction.Pediatric nephrology (Berlin, Germany) · 2021Article
- The Genomic Response to TGF-β1 Dictates Failed Repair and Progression of Fibrotic Disease in the Obstructed Kidney.Frontiers in cell and developmental biology · 2021Review
- Predicting outcomes and improving care in children with congenital kidney anomalies.Pediatric nephrology (Berlin, Germany) · 2020Article
- The role of urinary NGAL and serum cystatin C in assessing the severity of ureteropelvic junction obstruction in infants.Pediatric nephrology (Berlin, Germany) · 2020Article
- DAMPs in Unilateral Ureteral Obstruction.Frontiers in immunology · 2020Review
- Managing Ureteropelvic Junction Obstruction in the Young Infant.Frontiers in pediatrics · 2020Review
- Neonatal obstructive nephropathy induces necroptosis and necroinflammation.Scientific reports · 2019Article
- Use of MR Urography in Pediatric Patients.Current urology reports · 2018Review
- Candidate gene and mechanism investigations in congenital obstructive nephropathy based on bioinformatics analysis.Molecular medicine reports · 2018Article
- [Congenital dilatation of the upper urinary tract : Current diagnostic and treatment concepts].Der Urologe. Ausg. A · 2018Article
- Systems biology combining human- and animal-data miRNA and mRNA data identifies new targets in ureteropelvic junction obstruction.BMC systems biology · 2017Article
- Urinary Exosomes Contain MicroRNAs Capable of Paracrine Modulation of Tubular Transporters in Kidney.Scientific reports · 2017Article
- Urinary biomarkers for renal tract malformations.Expert review of proteomics · 2016Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital obstructive nephropathy (CON) is the leading cause of chronic kidney disease (CKD) in children. Anomalies of the urinary tract are often associated with abnormal nephrogenesis, which is compounded by obstructive injury and by maternal risk factors associated with low birth weight. Currently available fetal and postnatal imaging and analytes of amniotic fluid, urine, or blood lack predictive value. For ureteropelvic junction obstruction, biomarkers are needed for optimal timing of pyeloplasty; for posterior urethral valves, biomarkers of long-term prognosis and CKD are needed. The initial nephron number may be a major determinant of progression of CKD, and most patients with CON who progress to renal failure reach this point in adulthood, presumably compounded by episodes of acute kidney injury. Biomarkers of tubular injury may be of particular value in predicting the need for surgical intervention or in tracking progression of CKD, and must be adjusted for patient age. Discovery of new biomarkers may depend on "unbiased" proteomics, whereby patterns of urinary peptide fragments from patients with CON are analyzed in comparison to controls. Most promising are the analysis of urinary exosomes (restricting biomarkers to relevant tubular cells) and quantitative magnetic resonance imaging techniques allowing precise determination of nephron number and tubular mass. The greatest need is for large prospective multicenter studies with centralized biomarker sample repositories to follow patients with CON from fetal life through adulthood.
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