ArticleVeterinary research2015
Evaluation of humoral immune status in porcine epidemic diarrhea virus (PEDV) infected sows under field conditions.
Article in Veterinary research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- A novel cross-species vaccine design and nasal immunization strategy based on recombinantApplied and environmental microbiology · 2026Article
- Evaluation of the Prevention and Control Efficacy of Different Immunization Regimens Against Porcine Epidemic Diarrhea Virus.Transboundary and emerging diseases · 2026Article
- Dynamic Antibody Responses in Porcine Epidemic Diarrhea Virus-Infected Pigs and Correlation of Prepartum Serum, Oral Swabs, and Rectal Swabs With Postpartum Colostral IgA and IgG in Sows.Transboundary and emerging diseases · 2026Article
- Article
- Comparison of B cells' immune response induced by PEDV virulent and attenuated strains.Frontiers in microbiology · 2024Article
- Correlation between the IgG/IgA Antibody Response against PEDV Structural Protein and Virus Neutralization.Microbiology spectrum · 2023Article
- Article
- A therapeutic chimeric IgG/IgA expressed by CHO cells for oral treatment of PED in piglets.Frontiers in microbiology · 2022Article
- Analysis of the effect of feedback feeding on the farm-level occurrence of porcine epidemic diarrhea in Kagoshima and Miyazaki Prefectures, Japan.The Journal of veterinary medical science · 2021Article
- Porcine Coronaviruses: Overview of the State of the Art.Virologica Sinica · 2021Review
- Systemic and intestinal porcine epidemic diarrhea virus-specific antibody response and distribution of antibody-secreting cells in experimentally infected conventional pigs.Veterinary research · 2021Article
- Isolation, Identification, and Evaluation of the Pathogenicity of a Porcine Enterovirus G Isolated From China.Frontiers in veterinary science · 2021Article
- Porcine epidemic diarrhea virus (PEDV): An update on etiology, transmission, pathogenesis, and prevention and control.Virus research · 2020Review
- Development of indirect enzyme-linked immunosorbent assay for detection of porcine epidemic diarrhea virus specific antibodies (IgG) in serum of naturally infected pigs.BMC veterinary research · 2019Article
- Emerging and re-emerging coronaviruses in pigs.Current opinion in virology · 2019Review
- Virulence of current German PEDV strains in suckling pigs and investigation of protective effects of maternally derived antibodies.Scientific reports · 2017Article
- Lactogenic immunity and vaccines for porcine epidemic diarrhea virus (PEDV): Historical and current concepts.Virus research · 2016Review
- Characterization of anti-porcine epidemic diarrhea virus neutralizing activity in mammary secretions.Virus research · 2016Article
- Porcine epidemic diarrhea virus: An overview of current virological and serological diagnostic methods.Virus research · 2016Review
- Diagnostic evaluation of assays for detection of antibodies against porcine epidemic diarrhea virus (PEDV) in pigs exposed to different PEDV strains.Preventive veterinary medicine · 2016Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porcine epidemic diarrhea virus (PEDV) is an economically devastating enteric disease in the swine industry. The virus infects pigs of all ages, but it cause severe clinical disease in neonatal suckling pigs with up to 100% mortality. Currently, available vaccines are not completely effective and feedback methods utilizing PEDV infected material has variable success in preventing reinfection. Comprehensive information on the levels and duration of effector/memory IgA and IgG antibody secreting B cell response in the intestines and lymphoid organs of PEDV-infected sows, and their association with specific antibody levels in clinical samples such as plasma, oral fluid, and feces is important. Therefore, our goal in this study was to quantify PEDV specific IgA and IgG B cell responses in sows at approximately 1 and 6 months post-infection in commercial swine herds, including parity one and higher sows. Our data indicated that evaluation of both PEDV specific IgA and IgG antibody levels in the plasma and oral fluid (but not feces) samples is beneficial in disease diagnosis. PEDV specific B cell response in the intestine and spleen of infected sows decline by 6 months, and this associates with specific antibody levels in the plasma and oral fluid samples; but the virus neutralization titers in plasma remains high beyond 6 months post-infection. In conclusion, in sows infected with PEDV the presence of effector/memory B cell response and strong virus neutralization titers in plasma up to 6 months post-infection, suggests their potential to protect sows from reinfection and provide maternal immunity to neonates, but challenge studies are required to confirm such responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.