Evidence map›Paper›PMID 26667085›Full record

ArticleJournal of the American Heart Association2015

Neuropsychological Status and Structural Brain Imaging in Adolescents With Single Ventricle Who Underwent the Fontan Procedure.

David C Bellinger, Christopher G Watson, Michael J Rivkin, Richard L Robertson, Amy E Roberts, Christian Stopp, Carolyn Dunbar-Masterson, Dana Bernson, David R DeMaso, David Wypij and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 6 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 6 syntheses or guidelines pooled it, 163 citations in OpenAlex.

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  13. Childhood Neurocognitive Outcomes in Patients With Fontan Circulation.Journal of the American Heart Association · 2025
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

David C BellingerDepartment of Neurology, Boston Children's Hospital, Boston, MA (D.C.B., C.G.W., M.J.R.) Department of Psychiatry, Boston Children's Hospital, Boston, MA (D.C.B., M.J.R., D.R.D.M.) Department of Neurology, Harvard Medical School, Boston, MA (D.C.B., M.J.R.) Department of Psychiatry, Harvard Medical School, Boston, MA (D.C.B., D.R.D.M.).
Christopher G WatsonDepartment of Neurology, Boston Children's Hospital, Boston, MA (D.C.B., C.G.W., M.J.R.) Graduate Program for Neuroscience, Boston University, Boston, MA (C.G.W.).
Michael J RivkinDepartment of Neurology, Boston Children's Hospital, Boston, MA (D.C.B., C.G.W., M.J.R.) Department of Radiology, Boston Children's Hospital, Boston, MA (M.J.R., R.L.R.) Department of Psychiatry, Boston Children's Hospital, Boston, MA (D.C.B., M.J.R., D.R.D.M.) Department of Neurology, Harvard Medical School, Boston, MA (D.C.B., M.J.R.).
Richard L RobertsonDepartment of Radiology, Boston Children's Hospital, Boston, MA (M.J.R., R.L.R.) Department of Radiology, Harvard Medical School, Boston, MA (R.L.R.).
Amy E RobertsDepartment of Cardiology, Boston Children's Hospital, Boston, MA (A.E.R., C.S., C.D.M., D.B., D.W., J.W.N.) Department of Pediatrics, Harvard Medical School, Boston, MA (A.E.R., D.W., J.W.N.).
Christian StoppDepartment of Cardiology, Boston Children's Hospital, Boston, MA (A.E.R., C.S., C.D.M., D.B., D.W., J.W.N.).
Carolyn Dunbar-MastersonDepartment of Cardiology, Boston Children's Hospital, Boston, MA (A.E.R., C.S., C.D.M., D.B., D.W., J.W.N.).
Dana BernsonDepartment of Cardiology, Boston Children's Hospital, Boston, MA (A.E.R., C.S., C.D.M., D.B., D.W., J.W.N.).
David R DeMasoDepartment of Psychiatry, Boston Children's Hospital, Boston, MA (D.C.B., M.J.R., D.R.D.M.) Department of Psychiatry, Harvard Medical School, Boston, MA (D.C.B., D.R.D.M.).
David WypijDepartment of Cardiology, Boston Children's Hospital, Boston, MA (A.E.R., C.S., C.D.M., D.B., D.W., J.W.N.) Department of Pediatrics, Harvard Medical School, Boston, MA (A.E.R., D.W., J.W.N.) Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA (D.W.).
Jane W NewburgerDepartment of Cardiology, Boston Children's Hospital, Boston, MA (A.E.R., C.S., C.D.M., D.B., D.W., J.W.N.) Department of Pediatrics, Harvard Medical School, Boston, MA (A.E.R., D.W., J.W.N.).
Boston Children's Museum · USBoston Children's Hospital · USBoston University · USHarvard University · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Brain Structure and Function in Adolescents after the Fontan OperationR01HL096825 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI NEWBURGER, JANE W., RIVKIN, MICHAEL JOHN · 2009 to 2012
$2.9M
NCRR NIH HHS UL1 RR025758NHLBI NIH HHS R01 HL096825
6 · The paper itself

Abstract

backgroundFew studies have described the neuropsychological outcomes and frequency of structural brain or genetic abnormalities in adolescents with single ventricle who underwent the Fontan procedure. METHODS AND

resultsIn a cross-sectional, single-center study, we enrolled 156 subjects with single ventricle, mean age 14.5±2.9 years, who had undergone the Fontan procedure. Scores in the entire cohort on a standard battery of neuropsychological tests were compared with those of normative populations or to those of a group of 111 locally recruited healthy adolescents. They also underwent brain magnetic resonance imaging and were evaluated by a clinical geneticist. Genetic abnormalities were definite in 16 subjects (10%) and possible in 49 subjects (31%). Mean Full-Scale IQ was 91.6±16.8, mean Reading Composite score was 91.9±17.2, and mean Mathematics Composite score was 92.0±22.9, each significantly lower than the population means of 100±15. Mean scores on other neuropsychological tests were similarly lower than population norms. In multivariable models, risk factors for worse neuropsychological outcomes were longer total support and circulatory arrest duration at first operation, presence of a genetic abnormality, more operations and operative complications, more catheterization complications, and seizure history. The frequency of any abnormality on magnetic resonance imaging was 11 times higher among Fontan adolescents than referents (66% versus 6%); 19 (13%) patients had evidence of a stroke, previously undiagnosed in 7 patients (40%).

conclusionsThe neuropsychological deficits and high frequencies of structural brain abnormalities in adolescents who underwent the Fontan procedure highlight the need for research on interventions to improve the long-term outcomes in this high-risk group.

Indexed as

Fontan ProcedureAdolescentBrainChildCognition DisordersCross-Sectional StudiesFemaleGenetic Diseases, InbornHeart VentriclesHumansMagnetic Resonance ImagingMaleNeuroimagingNeuropsychological TestsYoung Adultcongenital heart defectsFontan proceduregeneticsmagnetic resonance imaging

Identifiers

PMID26667085
PMCPMC4845289
OpenAlexW2265129071

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.