ArticleBrain imaging and behavior2016
Cannabis and cocaine decrease cognitive impulse control and functional corticostriatal connectivity in drug users with low activity DBH genotypes.
Article in Brain imaging and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Is resting-state functional connectivity altered in regular cannabis users? A systematic review of the literature.Psychopharmacology · 2022Pooled it
- A systematic review of neuroimaging and acute cannabis exposure in age-of-risk for psychosis.Translational psychiatry · 2021Pooled it
- Detection of Δ9-Tetrahydrocannabinol Impairment Using Resting-State Functional Near-Infrared Spectroscopy: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Intoxication due to Δ9-tetrahydrocannabinol is characterized by disrupted prefrontal cortex activity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Trial
- Identification of ∆9-tetrahydrocannabinol (THC) impairment using functional brain imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Trial
- Effect of Δ9-Tetrahydrocannabinol on frontostriatal resting state functional connectivity and subjective euphoric response in healthy young adults.Drug and alcohol dependence · 2021Trial
- Reduced responsiveness of the reward system is associated with tolerance to cannabis impairment in chronic users.Addiction biology · 2021Trial
- Synthetic cannabinoid-induced changes in thalamo-prefrontal gamma synchrony and thalamic high-voltage spindles.Psychopharmacology · 2026Article
- EEG-based network dynamics in cannabis and polydrug use: a directed transfer function approach.Psychopharmacology · 2026Article
- Influence of cannabis potency on mental health outcomes among adolescents and young adults: scoping review.BJPsych open · 2026Review
- Acute cannabidiol (CBD), tetrahydrocannabinol (THC) and their mixture (THC:CBD) exert differential effects on brain activity and blood flow in rats: A translational neuroimaging study.Journal of psychopharmacology (Oxford, England) · 2026Article
- Individual and combined effects of cannabidiol and ΔJournal of psychopharmacology (Oxford, England) · 2022Article
- Functional brain connectomes reflect acute and chronic cannabis use.Scientific reports · 2022Article
- Cannabis Use and Neuroadaptation: A Call for ΔFrontiers in psychiatry · 2022Article
- Testing the validity and reliability of the Matching Familiar Figures Test-2021: An updated behavioral measure of reflection-impulsivity.Frontiers in psychology · 2022Article
- The Neurocognitive Effects of Cannabis Across the Lifespan.Current behavioral neuroscience reports · 2021Article
- The why behind the high: determinants of neurocognition during acute cannabis exposure.Nature reviews. Neuroscience · 2021Review
- Pharmacokinetic, behavioral, and brain activity effects of ΔNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Which came first: Cannabis use or deficits in impulse control?Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- Human Laboratory Models of Cannabis Use: Applications for Clinical and Translational Psychiatry Research.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dopamine β-hydroxylase (DβH) enzyme transforms dopamine into noradrenaline. We hypothesized that individuals with low activity DBH genotypes (rs1611115 CT/TT) are more sensitive to the influence of cannabis and cocaine on cognitive impulse control and functional connectivity in the limbic 'reward' circuit because they experience a drug induced hyperdopaminergic state compared to individuals with high activity DBH genotypes (rs1611115 CC). Regular drug users (N = 122) received acute doses of cannabis (450 μg/kg THC), cocaine HCl 300 mg and placebo. Cognitive impulse control was assessed by means of the Matching Familiar Figures Test (MFFT). Resting state fMRI was measured in a subset of participants to determine functional connectivity between the nucleus accumbens (NAc) and (sub)cortical areas. The influence of cannabis and cocaine on impulsivity and functional connectivity significantly interacted with DBH genotype. Both drugs increased cognitive impulsivity in participants with CT/TT genotypes but not in CC participants. Both drugs also reduced functional connectivity between the NAc and the limbic lobe, prefrontal cortex, striatum and thalamus and primarily in individuals with CT/TT genotypes. Correlational analysis indicated a significant negative association between cognitive impulsivity and functional connectivity in subcortical areas of the brain. It is concluded that interference of cannabis and cocaine with cognitive impulse control and functional corticostriatal connectivity depends on DBH genotype. The present data provide a neural substrate and behavioral mechanism by which drug users can progress to drug seeking and may also offer a rationale for targeted pharmacotherapy in chronic drug users with high risk DBH genotypes.
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