ArticleBMC neuroscience2015
Intracellular chloride concentration of the mouse vomeronasal neuron.
Article in BMC neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Zinc Inhibits the GABAInternational journal of molecular sciences · 2023Article
- WNK1 is a chloride-stimulated scaffold that regulates mTORC2 activity and ion transport.Journal of cell science · 2022Article
- Article
- NaCl Nanoparticles as a Cancer Therapeutic.Advanced materials (Deerfield Beach, Fla.) · 2019Article
- Signal Detection and Coding in the Accessory Olfactory System.Chemical senses · 2018Review
- CaThe Journal of biological chemistry · 2018Article
- Type 3 inositol 1,4,5-trisphosphate receptor is dispensable for sensory activation of the mammalian vomeronasal organ.Scientific reports · 2017Article
- Elevated Cytosolic Cl- Concentrations in Dendritic Knobs of Mouse Vomeronasal Sensory Neurons.Chemical senses · 2016Article
- CLIC1 Inhibition Attenuates Vascular Inflammation, Oxidative Stress, and Endothelial Injury.PloS one · 2016Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe vomeronasal organ (VNO) is specialized in detecting pheromone and heterospecific cues in the environment. Recent studies demonstrate the involvement of multiple ion channels in VNO signal transduction, including the calcium-activated chloride channels (CACCs). Opening of CACCs appears to result in activation of VNO neuron through outflow of Cl(-) ions. However, the intracellular Cl(-) concentration remains undetermined.
resultsWe used the chloride ion quenching dye, MQAE, to measure the intracellular Cl(-) concentration of VNO neuron in live VNO slices. The resting Cl(-) concentration in the VNO neurons is measured at 84.73 mM. Urine activation of the VNO neurons causes a drop in Cl(-) concentration, consistent with the notion of an efflux of Cl(-) to depolarize the cells. Similar observation is made for VNO neurons from mice with deletion of the transient receptor potential canonical channel 2 (TRPC2), which have a resting Cl(-) concentrations at 81 mM.
conclusionsThe VNO neurons rest at high intracellular Cl(-) concentration, which can lead to depolarization of the cell when chloride channels open. These results also provide additional support of TRPC2-independent pathway of VNO activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.