ReviewBiogerontology2016
Age-dependent motor unit remodelling in human limb muscles.
Review in Biogerontology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05060497 (DYNamic Assessment of Multi Organ Level Dysfunction in Patients Recovering From Covid-19), which is not on this map. Cited by 110 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
DYNamic Assessment of Multi Organ Level Dysfunction in Patients Recovering From Covid-19
Who cites it
110 citing papers in PubMed, 3 syntheses or guidelines pooled it, 168 citations in OpenAlex.
- Electrophysiological Signatures of Sarcopenia: A Systematic Review of sEMG Features, Fatigue Indices and AI-Based Classifiers.Sensors (Basel, Switzerland) · 2026Pooled it
- Exploring motor unit and neuromuscular junction dysfunction in aging and sarcopenia: insights from electromyography in systematic review.GeroScience · 2026Pooled it
- The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis.Journal of cachexia, sarcopenia and muscle · 2025Pooled it
- Optimization and Device-Level Validation of the i-Phagia Surface Electromyography Submental Sensor Patch for Swallowing Monitoring: A Randomized Crossover Design Study.Journal of speech, language, and hearing research : JSLHR · 2026Trial
- Trial
- Influence of nitrate supplementation on motor unit activity during recovery following a sustained ischemic contraction in recreationally active young males.European journal of nutrition · 2024Trial
- Effect of nitrate supplementation on skeletal muscle motor unit activity during isometric blood flow restriction exercise.European journal of applied physiology · 2022Trial
- Neuromuscular junction failure in sarcopenia is linked to NaV1.4 loss and reversed by ClC-1 inhibition.The Journal of clinical investigation · 2026Article
- The Impact of Ageing on Skeletal Muscle: Roles of Mitochondrial Dysregulation, Systemic Communication, and Exercise.Journal of cellular physiology · 2026Review
- Inflammaging-associated mitochondrial degeneration occurs in hypoglossal motor neurons prior to tongue muscle.GeroScience · 2026Article
- Co-Contraction Training Induces Muscle Hypertrophy but Not Strength Gains in Older Adults: A Controlled Intervention Study.Health science reports · 2026Article
- The evidence for old age motor neuron death: A scoping review.Physiological reports · 2026Article
- Exploring the effect of different neural strategies on the knee joint contact forces during walking in adults.Scientific reports · 2026Article
- Deficient Cardiolipin Remodelling Alters Muscle Fibre Composition and Neuromuscular Connectivity in Barth Syndrome.Journal of cachexia, sarcopenia and muscle · 2026Article
- Ageing does not impair motor neuron adaptations: comparable motor unit responses to strength training in young and older adults.The Journal of physiology · 2026Article
- Automating population construction and parallel simulation of biophysical models for neuromuscular cells: An inverse approach.PLoS computational biology · 2026Article
- Concurrent HIIT and Resistance Training for Musculoskeletal Function: A Systematic Review of Neuromuscular, Morphological, and Performance Adaptations.Life (Basel, Switzerland) · 2026Review
- Muscle strength, neuromuscular function, and functional measures across stages of chronic kidney disease.BMC nephrology · 2026Article
- Exercise during 14 days of head down tilt bedrest attenuates motor unit impairments in older humans.Experimental physiology · 2026Article
- Longitudinal changes in hand dominance and manual dexterity in normal aging and mild cognitive impairment (MCI): a kinematic study.Frontiers in aging neuroscience · 2026Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Voluntary control of skeletal muscle enables humans to interact with and manipulate the environment. Lower muscle mass, weakness and poor coordination are common complaints in older age and reduce physical capabilities. Attention has focused on ways of maintaining muscle size and strength by exercise, diet or hormone replacement. Without appropriate neural innervation, however, muscle cannot function. Emerging evidence points to a neural basis of muscle loss. Motor unit number estimates indicate that by age around 71 years, healthy older people have around 40 % fewer motor units. The surviving low- and moderate-threshold motor units recruited for moderate intensity contractions are enlarged by around 50 % and show increased fibre density, presumably due to collateral reinnervation of denervated fibres. Motor unit potentials show increased complexity and the stability of neuromuscular junction transmissions is decreased. The available evidence is limited by a lack of longitudinal studies, relatively small sample sizes, a tendency to examine the small peripheral muscles and relatively few investigations into the consequences of motor unit remodelling for muscle size and control of movements in older age. Loss of motor neurons and remodelling of surviving motor units constitutes the major change in ageing muscles and probably contributes to muscle loss and functional impairments. The deterioration and remodelling of motor units likely imposes constraints on the way in which the central nervous system controls movements.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.