ArticleMolecular plant pathology2016
Carbon regulation of environmental pH by secreted small molecules that modulate pathogenicity in phytopathogenic fungi.
Article in Molecular plant pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed.
- Insights into the Adaptation ofJournal of fungi (Basel, Switzerland) · 2026Article
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- Glutamate dehydrogenase 2 is required for virulence by facilitating fungal growth in the host hemocoel.Virulence · 2025Article
- Assessment of the Chemical Diversity and Functional Properties of Secondary Metabolites from the Marine FungusJournal of fungi (Basel, Switzerland) · 2024Article
- Dual Transcriptome Analysis Reveals the Changes in Gene Expression in Both Cotton andJournal of fungi (Basel, Switzerland) · 2024Article
- Exploitation of microbial activities at low pH to enhance planetary health.FEMS microbiology reviews · 2024Article
- Comparative Transcriptome Profiling of Cassava Tuberous Roots in Response to Postharvest Physiological Deterioration.International journal of molecular sciences · 2022Article
- ComparativeMicroorganisms · 2022Article
- Production of Primary Metabolites byMolecules (Basel, Switzerland) · 2022Article
- Fungal Contamination in Microalgal Cultivation: Biological and Biotechnological Aspects of Fungi-Microalgae Interaction.Journal of fungi (Basel, Switzerland) · 2022Review
- Plant-microbe interactions in the apoplast: Communication at the plant cell wall.The Plant cell · 2022Article
- Organic acid, a virulence factor for pathogenic fungi, causing postharvest decay in fruits.Molecular plant pathology · 2022Review
- Molecular basis for optimizing sugar metabolism and transport during fruit development.aBIOTECH · 2021Review
- The Effect of Environmental pH duringAntioxidants (Basel, Switzerland) · 2021Article
- Research Progress on Phytopathogenic Fungi and Their Role as Biocontrol Agents.Frontiers in microbiology · 2021Review
- Review of the Impact of Apple Fruit Ripening, Texture and Chemical Contents on Genetically Determined Susceptibility to Storage Rots.Plants (Basel, Switzerland) · 2020Review
- In silico definition of new ligninolytic peroxidase sub-classes in fungi and putative relation to fungal life style.Scientific reports · 2019Article
- Network analysis exposes core functions in major lifestyles of fungal and oomycete plant pathogens.BMC genomics · 2019Article
- Induced expression of the Fragaria × ananassa Rapid alkalinization factor-33-like gene decreases anthracnose ontogenic resistance of unripe strawberry fruit stages.Molecular plant pathology · 2019Article
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11 authors.
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Abstract
Fruit pathogens can contribute to the acidification or alkalinization of the host environment. This capability has been used to divide fungal pathogens into acidifying and/or alkalinizing classes. Here, we show that diverse classes of fungal pathogens-Colletotrichum gloeosporioides, Penicillium expansum, Aspergillus nidulans and Fusarium oxysporum-secrete small pH-affecting molecules. These molecules modify the environmental pH, which dictates acidic or alkaline colonizing strategies, and induce the expression of PACC-dependent genes. We show that, in many organisms, acidification is induced under carbon excess, i.e. 175 mm sucrose (the most abundant sugar in fruits). In contrast, alkalinization occurs under conditions of carbon deprivation, i.e. less than 15 mm sucrose. The carbon source is metabolized by glucose oxidase (gox2) to gluconic acid, contributing to medium acidification, whereas catalysed deamination of non-preferred carbon sources, such as the amino acid glutamate, by glutamate dehydrogenase 2 (gdh2), results in the secretion of ammonia. Functional analyses of Δgdh2 mutants showed reduced alkalinization and pathogenicity during growth under carbon deprivation, but not in high-carbon medium or on fruit rich in sugar, whereas analysis of Δgox2 mutants showed reduced acidification and pathogencity under conditions of excess carbon. The induction pattern of gdh2 was negatively correlated with the expression of the zinc finger global carbon catabolite repressor creA. The present results indicate that differential pH modulation by fruit fungal pathogens is a host-dependent mechanism, affected by host sugar content, that modulates environmental pH to enhance fruit colonization.
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