ArticleNature communications2015
An excitatory ventral hippocampus to lateral septum circuit that suppresses feeding.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed, 1 synthesis or guideline pooled it, 150 citations in OpenAlex.
- Missense variants in FRS3 affect body mass index in populations of diverse ancestries.Nature communications · 2025Pooled it
- The ventral hippocampus: computations, circuits and functions.Nature reviews. Neuroscience · 2026Review
- Oxytocin receptor signaling in the dorsal lateral septum is essential for social transmission of food preference in mice.PLoS biology · 2026Article
- Transsynaptic neural circuit mapping of ventral hippocampus motivational control systems.Brain structure & function · 2026Article
- Article
- Top-down regulation of ingestive behavior fragmentation.bioRxiv : the preprint server for biology · 2026Article
- Divergent Roles of Nucleus Accumbens D1- and D2-MSNs in Regulating Hedonic Feeding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Bisphenol S and Neurological Health: An Integrated Overview of Neurotoxicity and Underlying Mechanisms.Molecular neurobiology · 2026Review
- Comprehensive insights into emerging advances in the Neurobiology of anorexia.Journal of advanced research · 2026Review
- Sex-specific alterations in CRF and dopaminergic markers in the lateral septum and mesolimbic system following chronic high-fat diet exposure in rats.Frontiers in pharmacology · 2026Article
- High-fat diet disrupts a septal control on feeding to promote obesity in male mice.Nature communications · 2025Article
- Alcohol Facilitates Social Dominance Via Activating Dopamine 1 Receptor-expressing Neurons in the Lateral Septum of Male Mice.Molecular neurobiology · 2025Article
- Astrocyte specification in the mouse septum is shaped by both developmental origin and local signals.Nature neuroscience · 2025Article
- Ventral hippocampus neurons encode meal-related memory.Nature communications · 2025Article
- Article
- A food-sensitive olfactory circuit drives anticipatory satiety.Nature metabolism · 2025Article
- Separate orexigenic hippocampal ensembles shape dietary choice by enhancing contextual memory and motivation.Nature metabolism · 2025Article
- Mesoscopic connectome enters the new age of single-neuron projectome.Clinical and translational medicine · 2025Article
- Input-specific properties of excitatory synapses on oxytocin receptor-expressing neurons in the lateral septum.Journal of neurophysiology · 2024Article
- Hypothalamic AgRP neurons regulate the hyperphagia of lactation.Molecular metabolism · 2024Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous research has focused on feeding circuits residing in the hindbrain and midbrain that govern homeostatic or hedonic control of food intake. However, the feeding circuits controlling emotional or cognitive aspects of food intake are largely unknown. Here we use chemical genetics and optogenetic techniques to dissect appetite control circuits originating from ventral hippocampus (vHPC), a brain region implicated in emotion and cognition. We find that the vHPC projects functional glutamatergic synaptic inputs to the lateral septum (LS) and optogenetic activation of vHPC projections in LS reduces food intake. Consistently, food intake is suppressed by chemogenetic activation of glutamatergic neurons in the vHPC that project to the LS and inactivation of LS neurons blunts vHPC-induced suppression of feeding. Collectively, our results identify an anorexigenic neural circuit originating from vHPC to LS in the brain, revealing a potential therapeutic target for the treatment of anorexia or other appetite disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.