Evidence map›Paper›PMID 26666940›Full record

ArticleAntimicrobial agents and chemotherapy2015

Emergence of cfr-Mediated Linezolid Resistance in a Methicillin-Resistant Staphylococcus aureus Epidemic Clone Isolated from Patients with Cystic Fibrosis.

Juan de Dios Caballero, María Dolores Pastor, Ana Vindel, Luis Máiz, Genoveva Yagüe, Carme Salvador, Marta Cobo, María-Isabel Morosini, Rosa del Campo, Rafael Cantón and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Parallel evolution of linezolid-resistantMicrobiology spectrum · 2023
    Article
  6. Parallel Evolution of Linezolid ResistantbioRxiv : the preprint server for biology · 2023
    Article
  7. Communications medicine · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Frontiers in microbiology · 2018
    Review
  17. Review
  18. In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates from skin and soft tissue infections to vancomycin, daptomycin, linezolid and tedizolid.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Juan de Dios CaballeroServicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain.
María Dolores PastorServicio de Neumología, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
Ana VindelStaphylococcus Reference Laboratory, Servicio de Bacteriología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.
Luis MáizServicio de Neumología, Hospital Universitario Ramón y Cajal, Madrid, Spain.
Genoveva YagüeServicio de Microbiología, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
Carme SalvadorServicio de Microbiología, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
Marta CoboServicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.
María-Isabel MorosiniServicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain.
Rosa del CampoServicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain rosacampo@yahoo.com.
Rafael CantónServicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain.
GEIFQ Study Group
Hospital Universitario Virgen de la Arrixaca · ESInstituto Ramón y Cajal de Investigación Sanitaria · ESHospital Universitario Ramón y Cajal · ESInstituto de Salud Carlos III · ESRed Espanola de Investigacion en Patologia Infecciosa · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resistance to linezolid (LZD) in methicillin-resistant Staphylococcus aureus (MRSA) isolates from patients with cystic fibrosis (CF) is due mainly to ribosomal mutations. We report on four CF patients with LZD-resistant MRSA bronchopulmonary infections by strains carrying the cfr gene. Strains from one patient also harbored the G2576U mutation (23S rRNA) and the G139R substitution (L3 protein). All strains belonged to the epidemic clone ST125 MRSA IVc. Our results support the monitoring of LZD resistance emergence in CF and non-CF MRSA isolates.

Indexed as

AdolescentAdultAnti-Bacterial AgentsBacterial ProteinsCystic FibrosisDrug Resistance, BacterialFemaleHumansLinezolidMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsRibosomal Protein L3Ribosomal ProteinsRNA, Ribosomal, 23SStaphylococcal InfectionsYoung AdultAnti-Bacterial AgentsBacterial ProteinsCFR protein, Staphylococcus aureusLinezolidRibosomal Protein L3Ribosomal ProteinsRNA, Ribosomal, 23S

Identifiers

PMID26666940
PMCPMC4775957
OpenAlexW2196822447

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.