Evidence map›Paper›PMID 26666921›Full record

ArticleAntimicrobial agents and chemotherapy2015

Colistin-Resistant Acinetobacter baumannii Clinical Strains with Deficient Biofilm Formation.

Konstantina Dafopoulou, Basil Britto Xavier, An Hotterbeekx, Lore Janssens, Christine Lammens, Emmanuelle Dé, Herman Goossens, Athanasios Tsakris, Surbhi Malhotra-Kumar, Spyros Pournaras

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 47 citations in OpenAlex.

  1. A Novel Method to Monitor the Evolution of Antimicrobial Resistance inInternational journal of molecular sciences · 2026
    Article
  2. Review
  3. Colistin Resistance in Bacteria: Current Updates on Mechanism of Action and Combating Strategies.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. PmrAB, the two-component system ofJournal of bacteriology · 2024
    Article
  10. Frontiers in microbiology · 2024
    Review
  11. Phenotypic and genotypic characterization of clinicalJournal of Taibah University Medical Sciences · 2023
    Article
  12. Colistin Resistance inAntibiotics (Basel, Switzerland) · 2023
    Review
  13. Article
  14. Frontiers in microbiology · 2022
    Article
  15. Article
  16. Colistin Dependence in Extensively Drug-ResistantInternational journal of molecular sciences · 2021
    Article
  17. Article
  18. Article
  19. Lipopolysaccharide-DeficientFrontiers in microbiology · 2020
    Article
  20. A Porcine Wound Model ofAdvances in wound care · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Konstantina DafopoulouDepartment of Microbiology, National and Kapodistrian University of Athens, Athens, Greece Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
Basil Britto XavierLaboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
An HotterbeekxLaboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
Lore JanssensLaboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
Christine LammensLaboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
Emmanuelle DéCNRS UMR 6270, Polymers, Biopolymers and Surfaces Laboratory, University of Rouen, Rouen, France.
Herman GoossensLaboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
Athanasios TsakrisDepartment of Microbiology, National and Kapodistrian University of Athens, Athens, Greece.
Surbhi Malhotra-KumarLaboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
Spyros PournarasDepartment of Microbiology, National and Kapodistrian University of Athens, Athens, Greece spournaras@med.uoa.gr.
University of Antwerp · BENational and Kapodistrian University of Athens · GRUniversité de Rouen Normandie · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In two pairs of clinical colistin-susceptible/colistin-resistant (Cst(s)/Cst(r)) Acinetobacter baumannii strains, the Cst(r) strains showed significantly decreased biofilm formation in static and dynamic assays (P < 0.001) and lower relative fitness (P < 0.05) compared with those of the Cst(s) counterparts. The whole-genome sequencing comparison of strain pairs identified a mutation converting a stop codon to lysine (*241K) in LpsB (involved in lipopolysaccharide [LPS] synthesis) in one Cst(r) strain and a frameshift mutation in CarO and the loss of a 47,969-bp element containing multiple genes associated with biofilm production in the other.

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsAnti-Bacterial AgentsBacterial AdhesionBacterial Outer Membrane ProteinsBacterial ProteinsBiofilmsColistinDrug Resistance, Multiple, BacterialHumansLipopolysaccharidesMannosyltransferasesMicrobial Sensitivity TestsPorinsAnti-Bacterial AgentsBacterial Outer Membrane ProteinsBacterial ProteinsCarO protein, Acinetobacter baumanniiColistinLipopolysaccharidesLpsB protein, bacteriaMannosyltransferasesPorins

Identifiers

PMID26666921
PMCPMC4776000
OpenAlexW2205990437

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.