Evidence map›Paper›PMID 26666745›Full record

ReviewSports medicine (Auckland, N.Z.)2016

Role of Exercise-Induced Oxidative Stress in Sickle Cell Trait and Disease.

Erica N Chirico, Camille Faës, Philippe Connes, Emmanuelle Canet-Soulas, Cyril Martin, Vincent Pialoux

Abstract readReview
PubMed Publisher
In one paragraph

Review in Sports medicine (Auckland, N.Z.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Inflammation in sickle cell disease.Clinical hemorheology and microcirculation · 2018
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Erica N ChiricoEA 647 Centre de Recherche et d'Innovation sur le Sport, Université Claude Bernard Lyon 1, Université de Lyon, 69622, Villeurbanne, France.
Camille FaësEA 647 Centre de Recherche et d'Innovation sur le Sport, Université Claude Bernard Lyon 1, Université de Lyon, 69622, Villeurbanne, France.
Philippe ConnesEA 647 Centre de Recherche et d'Innovation sur le Sport, Université Claude Bernard Lyon 1, Université de Lyon, 69622, Villeurbanne, France.
Emmanuelle Canet-SoulasCardiovascular, Metabolism, Diabetes, and Nutrition (CarMeN INSERM U-1060), Faculty of Medicine Lyon Sud, Université Claude Bernard Lyon 1, Oullins, France.
Cyril MartinEA 647 Centre de Recherche et d'Innovation sur le Sport, Université Claude Bernard Lyon 1, Université de Lyon, 69622, Villeurbanne, France.
Vincent PialouxEA 647 Centre de Recherche et d'Innovation sur le Sport, Université Claude Bernard Lyon 1, Université de Lyon, 69622, Villeurbanne, France. vincent.pialoux@univ-lyon1.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sickle cell disease is a class of hemoglobinopathy in humans, which is the most common inherited disease in the world. Although complications of sickle cell disease start from polymerization of red blood cells during its deoxygenating phase, the oxidative stress resulting from the biological processes associated with this disease (ischaemic and hypoxic injuries, hemolysis and inflammation) has been shown to contribute to its pathophysiology. It is widely known that chronic exercise reduces oxidative stress in healthy people, mainly via improvement of antioxidant enzyme efficiency. In addition, recent studies in other diseases, as well as in sickle cell trait carriers and in a mouse model of sickle cell disease, have shown that regular physical activity could decrease oxidative stress. The purpose of this review is to summarize the role of oxidative stress in sickle cell disease and the effects of acute and chronic exercise on the pro-oxidant/antioxidant balance in sickle cell trait and sickle cell disease.

Indexed as

Anemia, Sickle CellAnimalsDisease Models, AnimalExerciseHemeHemoglobin, SickleHemolysisHumansHypoxiaIronMiceNADPH OxidasesNitric OxideOxidative StressReperfusion InjurySickle Cell TraitHemeHemoglobin, SickleIronNADPH OxidasesNitric OxideXanthine Oxidase

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.