Evidence map›Paper›PMID 26666743›Full record

ReviewSports medicine (Auckland, N.Z.)2016

Intramuscular Anabolic Signaling and Endocrine Response Following Resistance Exercise: Implications for Muscle Hypertrophy.

Adam M Gonzalez, Jay R Hoffman, Jeffrey R Stout, David H Fukuda, Darryn S Willoughby

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Sports medicine (Auckland, N.Z.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.

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  17. Role of Muscle LIM Protein in Mechanotransduction Process.International journal of molecular sciences · 2022
    Review
  18. Article
  19. Article
  20. Myokines and Resistance Training: A Narrative Review.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Adam M GonzalezDepartment of Health Professions, Hofstra University, Hempstead, NY, USA.
Jay R HoffmanInstitute of Exercise Physiology and Wellness, Sport and Exercise Science, College of Education and Human Performance, University of Central Florida, P.O. Box 161250, Orlando, FL, 32816-1250, USA. jay.hoffman@ucf.edu.
Jeffrey R StoutInstitute of Exercise Physiology and Wellness, Sport and Exercise Science, College of Education and Human Performance, University of Central Florida, P.O. Box 161250, Orlando, FL, 32816-1250, USA.
David H FukudaInstitute of Exercise Physiology and Wellness, Sport and Exercise Science, College of Education and Human Performance, University of Central Florida, P.O. Box 161250, Orlando, FL, 32816-1250, USA.
Darryn S WilloughbyExercise and Biochemical Nutrition Laboratory, Baylor University, Waco, TX, USA.
University of Central Florida · USBaylor University · USHofstra University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maintaining skeletal muscle mass and function is critical for disease prevention, mobility and quality of life, and whole-body metabolism. Resistance exercise is known to be a major regulator for promoting muscle protein synthesis and muscle mass accretion. Manipulation of exercise intensity, volume, and rest elicit specific muscular adaptations that can maximize the magnitude of muscle growth. The stimulus of muscle contraction that occurs during differing intensities of resistance exercise results in varying biochemical responses regulating the rate of protein synthesis, known as mechanotransduction. At the cellular level, skeletal muscle adaptation appears to be the result of the cumulative effects of transient changes in gene expression following acute bouts of exercise. Thus, maximizing the resistance exercise-induced anabolic response produces the greatest potential for hypertrophic adaptation with training. The mechanisms involved in converting mechanical signals into the molecular events that control muscle growth are not completely understood; however, skeletal muscle protein synthesis appears to be regulated by the multi-protein phosphorylation cascade, mTORC1 (mammalian/mechanistic target of rapamycin complex 1). The purpose of this review is to examine the physiological response to resistance exercise, with particular emphasis on the endocrine response and intramuscular anabolic signaling through mTORC1. It appears that resistance exercise protocols that maximize muscle fiber recruitment, time-under-tension, and metabolic stress will contribute to maximizing intramuscular anabolic signaling; however, the resistance exercise parameters for maximizing the anabolic response remain unclear.

Indexed as

Resistance TrainingAdaptation, PhysiologicalHormonesHumansHypertrophyIntercellular Signaling Peptides and ProteinsMechanistic Target of Rapamycin Complex 1Mechanotransduction, CellularMultiprotein ComplexesMuscle ProteinsMuscle, SkeletalTOR Serine-Threonine KinasesHormonesIntercellular Signaling Peptides and ProteinsMechanistic Target of Rapamycin Complex 1Multiprotein ComplexesMuscle ProteinsTOR Serine-Threonine Kinases

Identifiers

PMID26666743
OpenAlexW2203336434

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.