ArticleFoot & ankle international2016
Muscle and Joint Factors Associated With Forefoot Deformity in the Diabetic Neuropathic Foot.
Article in Foot & ankle international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Associations Between Diabetic Foot Deformity and the Intrinsic Foot Muscles: A Systematic Review.Journal of foot and ankle research · 2025Pooled it
- Surgical offloading procedures for diabetic foot ulcers compared to best non-surgical treatment: a study protocol for a randomized controlled trial.Journal of foot and ankle research · 2018Trial
- Foot-specific exercise intervention for forefoot deformity in individuals with type 2 diabetes and peripheral neuropathy: A randomized controlled clinical trial with 3-year follow-up.Brazilian journal of physical therapyTrial
- Synergistic effects of diabetic neuropathy and kidney function decline on second metatarsal skeletal health and foot function: a pilot study.JBMR plus · 2026Article
- Use of computed tomography to identify muscle quality subgroups, spatial mapping, and preliminary relationships to function in those with diabetic peripheral neuropathy.Gait & posture · 2024Article
- When, where, and why should we look for vestibular dysfunction in people with diabetes mellitus?Frontiers in rehabilitation sciences · 2023Review
- Adverse health correlates of intimate partner violence against older women: Mining electronic health records.PloS one · 2023Article
- Effect of Diabetes on Tendon Structure and Function: Not Limited to Collagen Crosslinking.Journal of diabetes science and technology · 2023Article
- Correlation analysis between foot deformity and diabetic foot with radiographic measurement.Frontiers in clinical diabetes and healthcare · 2023Article
- Diabetic foot ulcers: Classification, risk factors and management.World journal of diabetes · 2022Review
- A limited number of slices yields comparable results to all slices in foot intrinsic muscle deterioration ratio on computed tomography and magnetic resonance imaging.Journal of biomechanics · 2021Article
- Lower extremity MRI following 10-week supervised exercise intervention in patients with diabetic peripheral neuropathy.BMJ open diabetes research & care · 2021Article
- Simple model of arch support: Relevance to Charcot Neuroarthropathy.Clinical biomechanics (Bristol, Avon) · 2021Article
- Association of toe-extension movement pattern magnitude and variability during three functional tasks with diabetic foot complications.Clinical biomechanics (Bristol, Avon) · 2021Article
- Neuropathy, claw toes, intrinsic muscle volume, and plantar aponeurosis thickness in diabetic feet.BMC musculoskeletal disorders · 2020Article
- Skeletal Muscle Regeneration in Advanced Diabetic Peripheral Neuropathy.Foot & ankle international · 2020Article
- Multi-System Factors Associated with Metatarsophalangeal Joint Deformity in Individuals with Type 2 Diabetes.Journal of clinical medicine · 2020Article
- The Role of Physical Therapists in Fighting the Type 2 Diabetes Epidemic.The Journal of orthopaedic and sports physical therapy · 2020Article
- Foot function and strength of patients with diabetes grouped by ulcer risk classification (IWGDF).Diabetology & metabolic syndrome · 2019Article
- History, Prevalence and Assessment of Limited Joint Mobility, from Stiff Hand Syndrome to Diabetic Foot Ulcer Prevention: A Narrative Review of the Literature.Current diabetes reviews · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDiabetic forefoot joint deformities are a known risk factor for skin breakdown and amputation, but the causes of deformity are not well understood. The purposes of this study were to determine the effects of intrinsic foot muscle deterioration and limited ankle joint mobility on the severity of metatarsophalangeal joint (MTPJ) deformity, and determine the relationships between these potential contributing factors and indicators of diabetic complications (peripheral neuropathy and advanced glycation end products).
methodsA total of 34 participants with diabetic neuropathy (average age, 59 years; range 41-73) were studied. MTPJ angle and intrinsic foot muscle deterioration were measured with computed tomography and magnetic resonance imaging, respectively. Maximum ankle dorsiflexion was measured using kinematics. Skin intrinsic fluorescence served as a proxy measure for advanced glycation end product accumulation.
resultsTotal forefoot lean muscle volume (r = -0.52, P < .01) and maximum ankle dorsiflexion (r = -0.42, P < .05) were correlated with severity of MTPJ deformity. Together they explained 35% of the variance of MTPJ angle. Neuropathy was correlated with forefoot muscle deterioration (ρ = 0.53, P < .01). Skin intrinsic fluorescence was correlated to severity of neuropathy (r = 0.50, P < .01) but not maximum ankle dorsiflexion, or forefoot deterioration when controlling for neuropathy.
conclusionThese results suggest that the interplay of intrinsic foot muscle deterioration and limited ankle mobility may be the primary contributor to the development of MTPJ deformity. Identifying these muscle and ankle motion impairments as risk factors for MTPJ deformity supports the need for targeted interventions early in the disease process to slow, or possibly stop the progression of deformity over time and reduce the risk of amputation. LEVEL OF EVIDENCE: Level IV, case series.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.