Evidence map›Paper›PMID 26666586›Full record

ArticleScientific reports2015

Physical activity in adulthood: genes and mortality.

Sira Karvinen, Katja Waller, Mika Silvennoinen, Lauren G Koch, Steven L Britton, Jaakko Kaprio, Heikki Kainulainen, Urho M Kujala

Open access · goldAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Sira KarvinenDepartment of Biology of Physical Activity, University of Jyväskylä, P.O. Box 35, FI-40014 University of Jyväskylä, Jyväskylä, Finland.
Katja WallerDepartment of Health Sciences, University of Jyväskylä, P.O. Box 35, FI-40014 University of Jyväskylä, Jyväskylä, Finland.
Mika SilvennoinenDepartment of Biology of Physical Activity, University of Jyväskylä, P.O. Box 35, FI-40014 University of Jyväskylä, Jyväskylä, Finland.
Lauren G KochDepartment of Anesthesiology, University of Michigan Medical School, 2021 BSRB, 109 Zina Pitcher Place, Ann Arbor, Michigan, 48109-2200 USA.
Steven L BrittonDepartment of Anesthesiology, University of Michigan Medical School, 2021 BSRB, 109 Zina Pitcher Place, Ann Arbor, Michigan, 48109-2200 USA.
Jaakko KaprioDepartment of Public Health, P.O. Box 41, FI-00014 University of Helsinki, Helsinki, Finland.
Heikki KainulainenDepartment of Biology of Physical Activity, University of Jyväskylä, P.O. Box 35, FI-40014 University of Jyväskylä, Jyväskylä, Finland.
Urho M KujalaDepartment of Health Sciences, University of Jyväskylä, P.O. Box 35, FI-40014 University of Jyväskylä, Jyväskylä, Finland.
University of Jyväskylä · FIUniversity of Michigan–Ann Arbor · USUniversity of Helsinki · FI

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Genotype-Phenotype relationships underlying aerobic capacity and metabolic healthR01DK099034 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BRITTON, STEVEN LOYAL, BURANT, CHARLES F · 2014 to 2016
$1.4M
Resource for Rat Genetic Models of Aerobic CapacityR24OD010950 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BRITTON, STEVEN LOYAL · 2012 to 2013
$1.0M
NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK099034NIH HHS R24 OD010950
6 · The paper itself

Abstract

Observational studies report a strong inverse relationship between leisure-time physical activity and all-cause mortality. Despite suggestive evidence from population-based associations, scientists have not been able to show a beneficial effect of physical activity on the risk of death in controlled intervention studies among individuals who have been healthy at baseline. On the other hand, high cardiorespiratory fitness is known to be a strong predictor of reduced mortality, even more robust than physical activity level itself. Here, in both animals and/or human twins, we show that the same genetic factors influence physical activity levels, cardiorespiratory fitness, and risk of death. Previous observational follow-up studies in humans suggest that increasing fitness through physical activity levels could prolong life; however, our controlled interventional study with laboratory rats bred for low and high intrinsic fitness contrast with these findings. Also, we find no evidence for the suggested association using pairwise analysis among monozygotic twin pairs who are discordant in their physical activity levels. Based on both our animal and human findings, we propose that genetic pleiotropy might partly explain the frequently observed associations between high baseline physical activity and later reduced mortality in humans.

Indexed as

Genetic Association StudiesMortalityMotor ActivityAdultAnimalsFemaleFollow-Up StudiesHumansKaplan-Meier EstimateMaleRatsTwins, DizygoticTwins, MonozygoticYoung Adult

Identifiers

PMID26666586
PMCPMC4678877
OpenAlexW2287069713

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.