ReviewAllergology international : official journal of the Japanese Society of Allergology2016
Delayed anaphylaxis to alpha-gal, an oligosaccharide in mammalian meat.
Review in Allergology international : official journal of the Japanese Society of Allergology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 107 citations in OpenAlex.
- Review
- Article
- Mechanisms of IgE-mediated food allergy and the role of allergen-specific B cells.FEBS letters · 2026Review
- Ticked Off: Allergic Effector Cells in the Pathogenesis of Alpha-gal Syndrome.Current allergy and asthma reports · 2025Review
- Ticks of Delaware revisited: an updated checklist of hard ticks (Ixodidae) and first records of soft ticks (Argasidae) in the First State.Journal of medical entomology · 2025Article
- Pre-clinical strategies and emerging technologies driving advances in the alpha-gal syndrome.Allergology international : official journal of the Japanese Society of Allergology · 2025Review
- Alpha-Gal Sensitization Dynamics in Individuals After Tick Bites With or Without Erythema Migrans.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Article
- Onset of Alpha-Gal Syndrome after Tick Bite, Washington, USA.Emerging infectious diseases · 2025Article
- Flounder Roe Triggering α-Gal Syndrome: Hyosophorin as a Possible Allergen.Acta dermato-venereologica · 2025Article
- Dinutuximab beta versus historical controls in the treatment of relapsed neuroblastoma: unadjusted and adjusted indirect comparisons.Frontiers in oncology · 2025Article
- Allergenic potency of various foods of mammalian origin in patients with α-Gal syndrome.Allergy · 2025Article
- Article
- Intrinsic risk factors for alpha-gal syndrome in a case-control study, 2019 to 2020.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024Article
- Gene-edited pigs: a translational model for human food allergy against alpha-Gal and anaphylaxis.Frontiers in immunology · 2024Article
- Immunotherapy with biodegradable nanoparticles encapsulating the oligosaccharide galactose-alpha-1,3-galactose enhance immune tolerance against alpha-gal sensitization in a murine model of alpha-gal syndrome.Frontiers in allergy · 2024Article
- Review
- High levels of alpha-gal with large variation in the salivary glands of lone star ticks fed on human blood.Scientific reports · 2023Article
- Geographic Distribution of Suspected Alpha-gal Syndrome Cases - United States, January 2017-December 2022.MMWR. Morbidity and mortality weekly report · 2023Article
- Perioperative implications of patients with alpha gal allergies.Journal of clinical anesthesia · 2023Review
- Tick bite as a risk factor for alpha-gal-specific immunoglobulin E antibodies and development of alpha-gal syndrome.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2023Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
IgE-mediated hypersensitivity refers to immune reactions that can be rapidly progressing and, in the case of anaphylaxis, are occasionally fatal. To that end, identification of the associated allergen is important for facilitating both education and allergen avoidance that are essential to long-term risk reduction. As the number of known exposures associated with anaphylaxis is limited, discovery of novel causative agents is crucial to evaluation and management of patients with idiopathic anaphylaxis. Within the last 10 years several apparently separate observations were recognized to be related, all of which resulted from the development of antibodies to a carbohydrate moiety on proteins. Interestingly, the exposure differed from airborne allergens but was nevertheless capable of producing anaphylactic and hypersensitivity reactions. Our recent work has identified these responses as being due to a novel IgE antibody directed against a mammalian oligosaccharide epitope, galactose-alpha-1,3-galactose ("alpha-gal"). This review will present the historical summary of the identification of cetuximab hypersensitivity due to alpha-gal IgE and discuss the non-primate mammalian meat food allergy as well as current goals and directions of our research programs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.