Evidence map›Paper›PMID 26666357›Full record

ArticleThe journal of spinal cord medicine2017

Fasting serum blood measures of bone and lipid metabolism in children with myelomeningocele for early detection of cardiovascular and bone fragility risk factors.

Alexander Van Speybroeck, Nicole M Mueske, Steven D Mittelman, Richard K Kremer, Deirdre D Ryan, Tishya A L Wren

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of spinal cord medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Alexander Van Speybroecka Department of Pediatrics, Keck School of Medicine , University of Southern California , Los Angeles , CA , USA.
Nicole M Mueskeb Children's Orthopaedic Center, Children's Hospital Los Angeles , Los Angeles , CA , USA.
Steven D Mittelmana Department of Pediatrics, Keck School of Medicine , University of Southern California , Los Angeles , CA , USA.
Richard K Kremerc McGill University Health Centre , Montreal , Canada.
Deirdre D Ryana Department of Pediatrics, Keck School of Medicine , University of Southern California , Los Angeles , CA , USA.
Tishya A L Wrenb Children's Orthopaedic Center, Children's Hospital Los Angeles , Los Angeles , CA , USA.
Orthopaedic Center · USUniversity of Southern California · USChildren's Hospital of Los Angeles · USMcGill University Health Centre · CA

Funding

Risk Factors for Osteoporosis in Children & Adolescents with MyelomeningoceleR01HD059826 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI WREN, TISHYA A L · 2010 to 2014
$2.4M
CIHR MT-10839NICHD NIH HHS R01 HD059826
6 · The paper itself

Abstract

objectiveThis study examined serum levels in children with myelomeningocele to identify the prevalence of pre-clinical signs of disease.

designA prospective, cross-sectional study.

settingPatients were actively recruited from multidisciplinary care clinics at tertiary children's hospitals from 2010-2012. The control comparison group was recruited by word-of-mouth. PATIENTS: Twenty-eight children with myelomeningocele (93% Hispanic; 17 males; 10.0 ± 2.1 years) and 58 controls (84% Hispanic; 30 males; 10.4 ± 2.4 years) provided ≥ 8-hour fasting blood samples with concomitant dual-energy x-ray absorptiometry measurements of body fat.

interventionsNot applicable.

main outcome measuresThe serum analysis included a lipid panel (cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein), insulin, glucose, leptin, aspartate aminotransferase, alanine transaminase, alkaline phosphatase, albumin, creatinine, calcium, phosphatase, parathyroid hormone, and vitamin D.

resultsChildren with myelomeningocele had higher body fat (35.2% versus 29.9%, p=0.01) and altered lipid profiles (lower high-density lipoprotein levels, 43.9 mg/dL versus 51.6 mg/dL, P = 0.03) suggesting elevated risk of metabolic syndrome. They also had a higher prevalence of vitamin D deficiency (43% versus 17%, p=0.02) and significantly lower levels of calcium (9.4 mg/dL versus 9.7 mg/dL, P = 0.003) and alkaline phosphatase (187.0 U/L versus 237.0 U/L, P = 0.003). Unexpectedly children with myelomeningocele had lower parathyroid hormone levels (14.5 pg/mL versus 18.4 pg/mL, P = 0.02) than controls despite lower calcium, vitamin D and alkaline phosphatase levels. This suggests an alteration in the sensing mechanism or response of the parathyroid gland to normal physiological stimuli in patients with myelomeningocele.

conclusionsChildren with myelomeningocele have abnormal biochemical markers for cardiovascular disease, insulin resistance and bone and mineral metabolism. Early recognition and monitoring of these risk factors in patients with myelomeningocele may help prevent later complications.

Indexed as

Lipid MetabolismBiomarkersBone and BonesBone Diseases, MetabolicCardiovascular DiseasesCase-Control StudiesChildFastingFemaleHumansInsulin ResistanceMaleMeningomyeloceleBiomarkersmetabolic syndromemyelomeningocelepediatricsserum levelsspina bifida

Identifiers

PMID26666357
PMCPMC5430477
OpenAlexW2217393109

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.