ArticleMolecular psychiatry2016
Genetic and environmental determinants of violence risk in psychotic disorders: a multivariate quantitative genetic study of 1.8 million Swedish twins and siblings.
Article in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Non-psychopathology Related Outcomes Among Siblings of Individuals with Mental Illness: A Systematic Review.Clinical child and family psychology review · 2021Pooled it
- Risk factors for interpersonal violence: an umbrella review of meta-analyses.The British journal of psychiatry : the journal of mental science · 2018Pooled it
- Adolescents at the crossroads: genetic associations between psychotic symptoms and antisocial traits.European child & adolescent psychiatry · 2026Article
- Improving risk assessment in forensic mental health: Temporal validation and clinical refinement of the FoVOx risk tool.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Aberrant deaths: a conundrum in domestic homicide reviews.Psychiatry, psychology, and law : an interdisciplinary journal of the Australian and New Zealand Association of Psychiatry, Psychology and Law · 2026Article
- Homicide in the context of psychosis: analysis of prior service utilisation and age at onset of illness and violence.BJPsych open · 2023Article
- Post-traumatic stress disorder and the risk of violent crime conviction in Sweden: a nationwide, register-based cohort study.The Lancet. Public health · 2023Article
- Study on correlations of BDNF, PI3K, AKT and CREB levels with depressive emotion and impulsive behaviors in drug-naïve patients with first-episode schizophrenia.BMC psychiatry · 2023Article
- Effects of Psychiatric Disease Severity and Clinical Characteristics on Duration of High Violence Risk: A Perspective on Violence Prevention in the Psychiatric Ward.Neuropsychiatric disease and treatment · 2023Article
- No causal associations between childhood family income and subsequent psychiatric disorders, substance misuse and violent crime arrests: a nationwide Finnish study of >650 000 individuals and their siblings.International journal of epidemiology · 2021Article
- Patterns of Lifetime Criminality in Mentally Disordered Offenders - Findings From a Nationally Representative Cohort.Frontiers in psychiatry · 2021Article
- Violent outcomes in first-episode psychosis: A clinical cohort study.Early intervention in psychiatry · 2020Article
- Risk of Subjection to Violence and Perpetration of Violence in Persons With Psychiatric Disorders in Sweden.JAMA psychiatry · 2020Article
- Cognition and violent behavior in psychotic disorders: A nationwide case-control study.Schizophrenia research. Cognition · 2020Article
- Clonal Characteristics of T-Cell Receptor Repertoires in Violent and Non-violent Patients With Schizophrenia.Frontiers in psychiatry · 2018Article
- Aggressive Behavior Among Persons With Schizophrenia and Those Who Are Developing Schizophrenia: Attempting to Understand the Limited Evidence on Causality.Schizophrenia bulletin · 2017Review
- Neighborhood Influences on Violent Reoffending Risk in Released Prisoners Diagnosed With Psychotic Disorders.Schizophrenia bulletin · 2017Article
- Association Between Maternal Smoking During Pregnancy and Severe Mental Illness in Offspring.JAMA psychiatry · 2017Article
- Brain structure differences among male schizophrenic patients with history of serious violent acts: an MRI voxel-based morphometric study.BMC psychiatry · 2017Article
- Violence prevention in psychiatry: an umbrella review of interventions in general and forensic psychiatry.The journal of forensic psychiatry & psychology · 2017Article
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3 authors.
Funding
Abstract
Patients diagnosed with psychotic disorders (for example, schizophrenia and bipolar disorder) have elevated risks of committing violent acts, particularly if they are comorbid with substance misuse. Despite recent insights from quantitative and molecular genetic studies demonstrating considerable pleiotropy in the genetic architecture of these phenotypes, there is currently a lack of large-scale studies that have specifically examined the aetiological links between psychotic disorders and violence. Using a sample of all Swedish individuals born between 1958 and 1989 (n=3 332 101), we identified a total of 923 259 twin-sibling pairs. Patients were identified using the National Patient Register using validated algorithms based on International Classification of Diseases (ICD) 8-10. Univariate quantitative genetic models revealed that all phenotypes (schizophrenia, bipolar disorder, substance misuse, and violent crime) were highly heritable (h(2)=53-71%). Multivariate models further revealed that schizophrenia was a stronger predictor of violence (r=0.32; 95% confidence interval: 0.30-0.33) than bipolar disorder (r=0.23; 0.21-0.25), and large proportions (51-67%) of these phenotypic correlations were explained by genetic factors shared between each disorder, substance misuse, and violence. Importantly, we found that genetic influences that were unrelated to substance misuse explained approximately a fifth (21%; 20-22%) of the correlation with violent criminality in bipolar disorder but none of the same correlation in schizophrenia (Pbipolar disorder<0.001; Pschizophrenia=0.55). These findings highlight the problems of not disentangling common and unique sources of covariance across genetically similar phenotypes as the latter sources may include aetiologically important clues. Clinically, these findings underline the importance of assessing risk of different phenotypes together and integrating interventions for psychiatric disorders, substance misuse, and violence.
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