ArticleeNeuro
Competing Mechanisms of Gamma and Beta Oscillations in the Olfactory Bulb Based on Multimodal Inhibition of Mitral Cells Over a Respiratory Cycle.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 54 citations in OpenAlex.
- Theta oscillations are an organizational unit of odor processing in the olfactory bulb.Science advances · 2026Article
- Distinct goal location beta frequency dynamics in hippocampus and prefrontal cortex across learning.bioRxiv : the preprint server for biology · 2026Article
- Gamma and beta oscillatory signatures of the human olfactory bulb encode odor valence and sampling.iScience · 2026Article
- Stimulus-Induced Theta-Band LFP Oscillations Format Neuronal Representations of Social Chemosignals in the Mouse Accessory Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Brain Microtubule Electrical Oscillations-Empirical Mode Decomposition Analysis.Cellular and molecular neurobiology · 2023Article
- Early development of olfactory circuit function.Frontiers in cellular neuroscience · 2023Review
- Neuropsychiatric consequences of COVID-19 related olfactory dysfunction: could non-olfactory cortical-bound inputs from damaged olfactory bulb also contribute to cognitive impairment?Frontiers in neuroscience · 2023Article
- Connectivity and dynamics in the olfactory bulb.PLoS computational biology · 2022Article
- Linking α-synuclein-induced synaptopathy and neural network dysfunction in early Parkinson's disease.Brain communications · 2022Review
- Smell-induced gamma oscillations in human olfactory cortex are required for accurate perception of odor identity.PLoS biology · 2022Article
- Cell and circuit origins of fast network oscillations in the mammalian main olfactory bulb.eLife · 2021Article
- Learning improves decoding of odor identity with phase-referenced oscillations in the olfactory bulb.eLife · 2020Article
- Membrane potential resonance in non-oscillatory neurons interacts with synaptic connectivity to produce network oscillations.Journal of computational neuroscience · 2019Article
- Somatostatin Serves a Modulatory Role in the Mouse Olfactory Bulb: Neuroanatomical and Behavioral Evidence.Frontiers in behavioral neuroscience · 2019Article
- Working Memory 2.0.Neuron · 2018Review
- Pharmacological manipulation of the olfactory bulb modulates beta oscillations: testing model predictions.Journal of neurophysiology · 2018Article
- Generative Biophysical Modeling of Dynamical Networks in the Olfactory System.Methods in molecular biology (Clifton, N.J.) · 2018Article
- A coupled-oscillator model of olfactory bulb gamma oscillations.PLoS computational biology · 2017Article
- Intraglomerular gap junctions enhance interglomerular synchrony in a sparsely connected olfactory bulb network.The Journal of physiology · 2017Article
- Effects of the mode of re-socialization after juvenile social isolation on medial prefrontal cortex myelination and function.Scientific reports · 2017Article
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gamma (∼40-90 Hz) and beta (∼15-40 Hz) oscillations and their associated neuronal assemblies are key features of neuronal sensory processing. However, the mechanisms involved in either their interaction and/or the switch between these different regimes in most sensory systems remain misunderstood. Based on in vivo recordings and biophysical modeling of the mammalian olfactory bulb (OB), we propose a general scheme where OB internal dynamics can sustain two distinct dynamic states, each dominated by either a gamma or a beta regime. The occurrence of each regime depends on the excitability level of granule cells, the main OB interneurons. Using this model framework, we demonstrate how the balance between sensory and centrifugal input can control the switch between the two oscillatory dynamic states. In parallel, we experimentally observed that sensory and centrifugal inputs to the rat OB could both be modulated by the respiration of the animal (2-12 Hz) and each one phase shifted with the other. Implementing this phase shift in our model resulted in the appearance of the alternation between gamma and beta rhythms within a single respiratory cycle, as in our experimental results under urethane anesthesia. Our theoretical framework can also account for the oscillatory frequency response, depending on the odor intensity, the odor valence, and the animal sniffing strategy observed under various conditions including animal freely-moving. Importantly, the results of the present model can form a basis to understand how fast rhythms could be controlled by the slower sensory and centrifugal modulations linked to the respiration. Visual Abstract: See Abstract.
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