ReviewEye and vision (London, England)2015
Collagen cross-linking: when and how? A review of the state of the art of the technique and new perspectives.
Review in Eye and vision (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 106 citations in OpenAlex.
- A prospective randomized self-controlled study of LASIK combined with accelerated cross-linking for high myopia in Chinese: 24-month follow-up.BMC ophthalmology · 2022Trial
- The efficiency and safety of oxygen-supplemented accelerated transepithelial corneal cross-linking.International ophthalmology · 2021Trial
- Trial
- N, S Co-Doped Carbon Quantum Dots-Riboflavin Composite Photosensitizers for Enhanced Iontophoresis-Assisted Corneal Cross-Linking.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Trends in the Management of Keratoconus in Australia.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- The Clinical Significance of the Early Screening of Keratoconus and Its Impact on Maintaining Quality of Life.Life (Basel, Switzerland) · 2026Article
- Oxygen-releasing microneedles enhance the therapeutic effect of corneal ectasia by increasing corneal oxygen content and riboflavin concentration during cross-linking.Materials today. Bio · 2025Article
- Computational and Experimental Characterization of Aligned Collagen across Varied Crosslinking Degrees.Micromachines · 2024Article
- Successful Collagen Crosslinking in a Patient With Keratoconus and Systemic Scleroderma.Cureus · 2024Article
- An integrated model of the human cornea as a linear biaxial birefringent medium.Scientific reports · 2024Article
- Influence of Keratoconus Severity on Detecting True Progression with Scheimpflug Imaging and Anterior Segment Optical Coherence Tomography.Life (Basel, Switzerland) · 2023Article
- Management of keratoconus: an updated review.Frontiers in medicine · 2023Review
- Evaluation of unilateral corneal collagen cross-linking on fellow untreated eyes of patients with keratoconus.Arquivos brasileiros de oftalmologia · 2022Article
- Posterior corneal elevation changes and characteristic analysis 1 year after corneal collagen cross-linking for keratoconus.International ophthalmology · 2022Article
- Outcomes of customized topographic guided epithelial debridement for corneal collagen cross-linking.International ophthalmology · 2022Article
- Development of a decellularized meniscus matrix-based nanofibrous scaffold for meniscus tissue engineering.Acta biomaterialia · 2021Article
- The association between oxidative stress and corneal hysteresis in patients with glaucoma.Scientific reports · 2020Article
- Safety, Efficacy, and Predictive Factors of Conventional Epithelium-Off Corneal Crosslinking in the Treatment of Progressive Keratoconus.Journal of ophthalmology · 2020Article
- Effects of collagen crosslinking on porcine and human tarsal plate.BMC ophthalmology · 2019Article
- Correlation of central and peripheral keratometric parameters after corneal collagen cross-linking in keratoconus patients.International ophthalmology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the late 1990s corneal crosslinking (CXL) has been proposed as a new possibility to stop progression of keratoconus or secondary corneal ectasia, with the promising aim to prevent progressive visual loss due to the evolution of the pathology and to delay or avoid invasive surgical procedures such as corneal transplantation. The possibility of strengthening corneal tissue by means of a photochemical reaction of corneal collagen by the combined action of Riboflavin and ultraviolet A irradiation (UVA), radically modified the conservative management of progressive corneal ectasia. This is a review of the state of the art of CXL, reporting basic and clinical evidence. The paper describes basic principles, advantages and limits of different CXL techniques and possible future evolution of the procedure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.