Evidence map›Paper›PMID 26665098›Full record

ArticleOrthopaedic journal of sports medicine2015

Autologous Platelet-Rich Plasma Preparations: Influence of Nonsteroidal Anti-inflammatory Drugs on Platelet Function.

Gert Schippinger, Florian Prüller, Manuela Divjak, Elisabeth Mahla, Florian Fankhauser, Steve Rackemann, Reinhard Bernd Raggam

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Orthopaedic journal of sports medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

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  11. Allogenic platelet-rich plasma for treatment of knee and hip osteoarthritis.Frontiers in pain research (Lausanne, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gert SchippingerSportchirurgieplus-Clinical Center for Sports Medicine and Orthopaedic Surgery, Graz, Austria.
Florian PrüllerClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria. ; Research Unit for Perioperative Platelet Function, Medical University of Graz, Graz, Austria.
Manuela DivjakClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria. ; Research Unit for Perioperative Platelet Function, Medical University of Graz, Graz, Austria.
Elisabeth MahlaResearch Unit for Perioperative Platelet Function, Medical University of Graz, Graz, Austria. ; Department of Anesthesiology and Intensive Care Medicine, Medical University of Graz, Graz, Austria.
Florian FankhauserSportchirurgieplus-Clinical Center for Sports Medicine and Orthopaedic Surgery, Graz, Austria.
Steve RackemannDepartment of Health Sciences, Griffith University, Gold Coast, Queensland, Australia.
Reinhard Bernd RaggamClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria. ; Research Unit for Perioperative Platelet Function, Medical University of Graz, Graz, Austria.
Medical University of Graz · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAutologous platelet-rich plasma (PRP) has been widely used for the treatment of sports injuries. It has been associated with improved healing and regeneration of soft tissues in elite athletes. Athletes are commonly receiving nonsteroidal anti-inflammatory drugs (NSAIDs). As yet, the effect of these drugs on platelet function in PRP formulations has not been taken into consideration. HYPOTHESIS: The function of platelets in PRP produced under the influence of NSAIDs is inhibited and may lessen a possible healing effect on the site of injury. STUDY

designControlled laboratory study.

methodsPRP was collected from patients receiving NSAIDs after elective orthopaedic surgery, and platelet function was evaluated using light transmission aggregometry (LTA). Results were compared with those obtained from healthy volunteers without a history of NSAID intake during the previous 2 weeks. Two different systems for blood collection and PRP production (Arthrex ACP double-syringe system and standard 4.5-mL sodium citrate blood collection tubes) were used and compared regarding the quality of PRP that was produced.

resultsFor both groups, the baseline platelet counts of whole blood and the platelet counts of PRP formulations were found to be in the normal range. Both collection systems for PRP produced comparable results without significant differences between the groups. Platelet function testing with LTA revealed significantly impaired platelet aggregation in both PRP preparations, obtained from patients taking NSAIDs, irrespective of the type of NSAID (P < .001). All subjects from the control group showed normal platelet aggregation patterns when tested with LTA.

conclusionAutologous PRP produced from subjects after NSAID medication shows significantly impaired platelet function and may result in lower quality regarding the content of bioactive compounds. CLINICAL RELEVANCE: If required, the administration of NSAIDs should be performed after blood collection for preparation of autologous PRP; otherwise, the therapeutic effect may be limited.

Indexed as

nonsteroidal anti-inflammatory drugsplatelet functionplatelet-rich plasma

Identifiers

PMID26665098
PMCPMC4622369
OpenAlexW2134057773

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.