ArticleBioMed research international2015
Effects of Etanercept against Transient Cerebral Ischemia in Diabetic Rats.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Ischemic stroke: molecular mechanisms of blood-brain barrier dysfunction and opportunities for drug development.Fluids and barriers of the CNS · 2026Review
- The diabetes mellitus multimorbidity network in hospitalized patients over 50 years of age in China: data mining of medical records.BMC public health · 2024Article
- TFNR2 in Ischemia-Reperfusion Injury, Rejection, and Tolerance in Transplantation.Frontiers in immunology · 2022Review
- Cytokines as therapeutic targets for cardio- and cerebrovascular diseases.Basic research in cardiology · 2021Review
- Melatonin suppresses the brain injury after cerebral ischemia/reperfusion in hyperglycaemic rats.Research in pharmaceutical sciences · 2020Article
- Article
- Post-stroke inflammation-target or tool for therapy?Acta neuropathologica · 2019Review
- "Inflammatory skin march" in atopic dermatitis and psoriasis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Review
- Hyperglycemia aggravates decreases of PEA-15 and its two phosphorylated forms in cerebral ischemia.The Journal of veterinary medical science · 2017Article
- Cardiovascular and Metabolic Diseases Comorbid with Psoriasis: Beyond the Skin.Internal medicine (Tokyo, Japan) · 2017Review
- Perispinal Delivery of CNS Drugs.CNS drugs · 2016Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus is known to exacerbate acute cerebral ischemic injury. Previous studies have demonstrated that infarction volumes caused by transient cerebral ischemia were greater in diabetic rats than in nondiabetic rats. Tumor necrosis factor-α (TNF-α) is a proinflammatory protein produced in the brain in response to cerebral ischemia that promotes apoptosis. Etanercept (ETN), a recombinant TNF receptor (p75)-Fc fusion protein, competitively inhibits TNF-α. Therefore, we evaluated the neuroprotective effects of chronic or acute treatment with ETN on cerebral injury caused by middle cerebral artery occlusion/reperfusion (MCAO/Re) in rats with streptozotocin-induced diabetes. Furthermore, we evaluated the effects of ETN against the apoptosis and myeloperoxidase activity. Single administration of ETN before MCAO significantly suppressed exacerbation of cerebral damage in nondiabetic rats, as assessed by infarct volume. In contrast, the diabetic state markedly aggravated MCAO/Re-induced cerebral damage despite ETN treatment within 24 h before MCAO. However, the damage was improved by repeated administration of ETN at 900 μg/kg/daily in rats in an induced diabetic state. These results suggested that repeated administration of ETN can prevent exacerbation of cerebral ischemic injury in the diabetic state and is mainly attributed to anti-inflammatory effects.
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