Evidence map›Paper›PMID 26664965›Full record

ReviewFrontiers in veterinary science2015

The Gut Microbiome and Its Potential Role in the Development and Function of Newborn Calf Gastrointestinal Tract.

Nilusha Malmuthuge, Philip J Griebel, Le Luo Guan

Abstract readReview
In one paragraph

Review in Frontiers in veterinary science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

139 citing papers in PubMed.

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  17. Biology · 2025
    Article
  18. Review
  19. Microorganisms · 2025
    Article
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79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nilusha MalmuthugeDepartment of Agricultural, Food and Nutritional Science, University of Alberta , Edmonton, AB , Canada.
Philip J GriebelVaccine and Infectious Disease Organization, University of Saskatchewan , Saskatoon, SK , Canada ; School of Public Health, University of Saskatchewan , Saskatoon, SK , Canada.
Le Luo GuanDepartment of Agricultural, Food and Nutritional Science, University of Alberta , Edmonton, AB , Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A diverse microbial population colonizes the sterile mammalian gastrointestinal tract during and after the birth. There is increasing evidence that this complex microbiome plays a crucial role in the development of the mucosal immune system and influences newborn health. Microbial colonization is a complex process influenced by a two-way interaction between host and microbes and a variety of external factors, including maternal microbiota, birth process, diet, and antibiotics. Following this initial colonization, continuous exposure to host-specific microbes is not only essential for development and maturation of the mucosal immune system but also the nutrition and health of the animal. Thus, it is important to understand host-microbiome interactions within the context of individual animal species and specific management practices. Data is now being generated revealing significant associations between the early microbiome, development of the mucosal immune system, and the growth and health of newborn calves. The current review focuses on recent information and discusses the limitation of current data and the potential challenges to better characterizing key host-specific microbial interactions. We also discuss potential strategies that may be used to manipulate the early microbiome to improve production and health during the time when newborn calves are most susceptible to enteric disease.

Indexed as

enteric infectionsgut developmentgut microbiotamucosal immune systemneonatal ruminants

Identifiers

PMID26664965
PMCPMC4672224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.