Evidence map›Paper›PMID 26664889›Full record

ArticleFrontiers in cardiovascular medicine2015

Identification of Human Papilloma Viruses in Atheromatous Coronary Artery Disease.

James S Lawson, Wendy K Glenn, Dinh D Tran, Christopher C Ngan, Johan A Duflou, Noel J Whitaker

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. HPV and coronary diseases in menopausal women: an integrative review.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2024
    Review
  6. Article
  7. Observational
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  9. Article
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  11. ApoB-Specific CD4Cells · 2021
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Viral infection and atherosclerosis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

James S LawsonSchool of Biotechnology and Biomolecular Sciences, University of New South Wales , Sydney, NSW , Australia.
Wendy K GlennSchool of Biotechnology and Biomolecular Sciences, University of New South Wales , Sydney, NSW , Australia.
Dinh D TranSchool of Biotechnology and Biomolecular Sciences, University of New South Wales , Sydney, NSW , Australia.
Christopher C NganSchool of Biotechnology and Biomolecular Sciences, University of New South Wales , Sydney, NSW , Australia.
Johan A DuflouDepartment of Forensic Medicine, The University of Sydney , Sydney, NSW , Australia.
Noel J WhitakerSchool of Biotechnology and Biomolecular Sciences, University of New South Wales , Sydney, NSW , Australia.
UNSW Sydney · AUUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo identify human papilloma viruses (HPV) in atheromatous coronary arteries.

backgroundAtheromatous arterial disease is primarily an initial inflammatory response to unknown stimuli. The crucial question is "what causes the initial inflammation in atheromatous disease?" HPV infections may be relevant as US women with vaginal, high risk for cancer, HPV infections, are at up to threefold increased risk of cardiovascular disease as compared with vaginal HPV-negative women. These studies did not include analyses of HPV in atheromatous coronary arteries.

methodsAtheromatous coronary arteries were identified and collected from 20 deceased donors. Polymerase Chain Reaction techniques were used to identify HPV gene sequences. Immunohistochemistry methods were used to identify HPV E7 proteins.

resultsHPV types 16 and 18 were identified in 11 (55%) of 20 specimens. HPV E7 protein was identified in 10 (50%) of 20 specimens. Positive and negative HPV identification and HPV E7 expression in coronary smooth muscle cells were significantly correlated (cc = 0.503, p = 0.024). The HPV E7 proteins were expressed in smooth muscle cells and plasma cells, foam cells, and macrophages located in the atheromatous plaque. HPV E7 proteins were not expressed in infiltrating lymph cells.

conclusionHPV gene sequences were identified in 55% of atheromatous coronary arteries and may have a role in coronary artery disease.

Indexed as

atheromacoronary artery diseasecoronary vessel anomaliesHPV E7 proteinhuman papillomavirusinflammation

Identifiers

PMID26664889
PMCPMC4671338
OpenAlexW1515524518

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.