Evidence map›Paper›PMID 26664885›Full record

ReviewFrontiers in cardiovascular medicine2015

Novel Molecular Approaches in Heart Failure: Seven Trans-Membrane Receptors Signaling in the Heart and Circulating Blood Leukocytes.

Gabriele Giacomo Schiattarella, Fabio Magliulo, Fabio Cattaneo, Giuseppe Gargiulo, Anna Sannino, Anna Franzone, Marco Oliveti, Cinzia Perrino, Bruno Trimarco, Giovanni Esposito

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cardiovascular medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Gabriele Giacomo SchiattarellaDepartment of Advanced Biomedical Sciences, Federico II University , Naples , Italy.
Fabio MagliuloDepartment of Advanced Biomedical Sciences, Federico II University , Naples , Italy.
Fabio CattaneoDepartment of Advanced Biomedical Sciences, Federico II University , Naples , Italy ; Department of Molecular Medicine and Medical Biotechnology, Federico II University , Naples , Italy.
Giuseppe GargiuloDepartment of Advanced Biomedical Sciences, Federico II University , Naples , Italy.
Anna SanninoDepartment of Advanced Biomedical Sciences, Federico II University , Naples , Italy.
Anna FranzoneDepartment of Cardiology, Swiss Cardiovascular Center Bern , Bern , Switzerland.
Marco OlivetiDepartment of Advanced Biomedical Sciences, Federico II University , Naples , Italy.
Cinzia PerrinoDepartment of Advanced Biomedical Sciences, Federico II University , Naples , Italy.
Bruno TrimarcoDepartment of Advanced Biomedical Sciences, Federico II University , Naples , Italy.
Giovanni EspositoDepartment of Advanced Biomedical Sciences, Federico II University , Naples , Italy.
Federico II University Hospital · ITSwiss Continence Foundation · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart failure (HF) is the result of molecular, cellular, and structural changes induced by cardiac load or injury. A complex network of signaling pathways have been involved in the development and progression of cardiac dysfunction. In this review, we summarize the pivotal role of seven trans-membrane receptors (7TMRs), also called G-protein-coupled receptors (GPCRs), in HF. Moreover, we will discuss the current knowledge on the potential mirroring of 7TMR signaling between circulating blood leukocytes and the heart, and the related future possibilities in the management of HF patients.

Indexed as

cardiac remodelingheart failureleukocytesseven trans-membrane receptors

Identifiers

PMID26664885
PMCPMC4671356
OpenAlexW2035945680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.