ArticleOxidative medicine and cellular longevity2016
The Effect of Lycopene Preexposure on UV-B-Irradiated Human Keratinocytes.
Article in Oxidative medicine and cellular longevity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 56 citations in OpenAlex.
- Lycopene, Carotenoids, and Retinoids in Cancer Chemoprevention: Molecular Mechanisms and Clinical Implications.Nutrients · 2026Review
- Tomato Pomace: Underestimated Sustainable Cosmetic/Pharmaceutical Raw Source.Molecules (Basel, Switzerland) · 2025Review
- Extraction and Optimization of Lycopene From Selected Fruits and Their Assessment as an Ultraviolet Ray Protectant forFood science & nutrition · 2025Article
- Nutraceutical Interventions for Mitigating Skin Ageing: Analysis of Mechanisms and Efficacy.Current pharmaceutical design · 2025Review
- Anti-Aging Effect of Traditional Plant-Based Food: An Overview.Foods (Basel, Switzerland) · 2024Review
- Skin Protection by Carotenoid Pigments.International journal of molecular sciences · 2024Review
- A causality between fruit consumption and colorectal cancer: a two-sample Mendelian randomization analysis.Frontiers in oncology · 2024Article
- Vegetable as a Source of Bioactive Compounds with Photoprotective Properties: Implication in the Aging Process.Nutrients · 2023Review
- Antioxidant Characterization of Six Tomato Cultivars and Derived Products Destined for Human Consumption.Antioxidants (Basel, Switzerland) · 2023Article
- Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases.Antioxidants (Basel, Switzerland) · 2022Review
- Phyto-Phospholipid Conjugated Scorpion Venom Nanovesicles as Promising Carrier That Improves Efficacy of Thymoquinone against Adenocarcinoma Human Alveolar Basal Epithelial Cells.Pharmaceutics · 2021Article
- Carotenoids from Persimmon (Pharmaceutics · 2021Article
- Extenuating role of lycopene against 254-nm UV-C radiation-mediated damages in Allium cepa L. roots.Environmental science and pollution research international · 2021Article
- Association Between Micronutrient Concentrations and Human Epididymis Protein 4.Journal of inflammation research · 2021Article
- Review
- Fucoxanthin and Rosmarinic Acid Combination Has Anti-Inflammatory Effects through Regulation of NLRP3 Inflammasome in UVB-Exposed HaCaT Keratinocytes.Marine drugs · 2019Article
- Carotenoids from UV-resistant Antarctic Microbacterium sp. LEMMJ01.Scientific reports · 2019Article
- Antioxidants from Plants Protect against Skin Photoaging.Oxidative medicine and cellular longevity · 2018Review
- 36H: A Novel Potent Inhibitor for Antimelanogenesis.Oxidative medicine and cellular longevity · 2018Article
- Phytochemicals for the Prevention of Photocarcinogenesis.Photochemistry and photobiology · 2017Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lycopene has been reported as the antioxidant most quickly depleted in skin upon UV irradiation, and thus it might play a protective role. Our goal was to investigate the effects of preexposure to lycopene on UV-B-irradiated skin cells. Cells were exposed for 24 h to 10 M lycopene, and subsequently irradiated and left to recover for another 24 h period. Thereafter, several parameters were analyzed by FCM and RT-PCR: genotoxicity/clastogenicity by assessing the cell cycle distribution; apoptosis by performing the Annexin-V assay and analyzing gene expression of apoptosis biomarkers; and oxidative stress by ROS quantification. Lycopene did not significantly affect the profile of apoptotic, necrotic and viable cells in nonirradiated cells neither showed cytostatic effects. However, irradiated cells previously treated with lycopene showed an increase in both dead and viable subpopulations compared to nonexposed irradiated cells. In irradiated cells, lycopene preexposure resulted in overexpression of BAX gene compared to nonexposed irradiated cells. This was accompanied by a cell cycle delay at S-phase transition and consequent decrease of cells in G0/G1 phase. Thus, lycopene seems to play a corrective role in irradiated cells depending on the level of photodamage. Thus, our findings may have implications for the management of skin cancer.
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Registered trials
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