ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2015
Biochemical changes in blood of type 2 diabetes with and without metabolic syndrome and their association with metabolic syndrome components.
Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Trial
- Hemorheological Alterations as a Driver of Microangiopathy in Diabetic Kidney Disease-The Role of Erythrocyte.International journal of molecular sciences · 2026Review
- Metabolic dysfunction-associated steatotic liver disease and bone mineral density in type 2 diabetes mellitus: insights from a single-center cross-sectional study in North India.Frontiers in endocrinology · 2026Article
- Influence of Age, Gender, Frailty, and Body Mass Index on Serum IL-17A Levels in Mature Type 2 Diabetic Patients.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Fluorescence-Based Portable Assays for Detection of Biological and Chemical Analytes.Sensors (Basel, Switzerland) · 2023Review
- Long-term GABA administration improves FNDC5, TFAM, and UCP3 mRNA expressions in the skeletal muscle and serum irisin levels in chronic type 2 diabetic rats.Naunyn-Schmiedeberg's archives of pharmacology · 2022Article
- Determination of plasma and erythrocyte levels of copper, magnesium and zinc by atomic absorption spectrometry in type-2 diabetes mellitus patients with metabolic syndrome.Research in pharmaceutical sciences · 2022Article
- Cardiovascular Risk Factors and Physical Activity for the Prevention of Cardiovascular Diseases in the Elderly.International journal of environmental research and public health · 2021Review
- Do We Store Packed Red Blood Cells under "Quasi-Diabetic" Conditions?Biomolecules · 2021Review
- Oxidant/antioxidant status in Type-2 diabetes mellitus patients with metabolic syndrome.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Article
- Susceptibility for Some Infectious Diseases in Patients With Diabetes: The Key Role of Glycemia.Frontiers in public health · 2021Review
- Association between a novel G94A single nucleotide polymorphism inJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2019Article
- Metabolic syndrome in hypertensive women in the age of menopause: a case study on data from general practice electronic health records.BMC medical informatics and decision making · 2018Article
- Effect of fermented camel milk on glucose metabolism, insulin resistance, and inflammatory biomarkers of adolescents with metabolic syndrome: A double-blind, randomized, crossover trial.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2018Article
- Association between unfavorable lipid profile and glycemic control in patients with type 2 diabetes mellitus.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2017Article
- Erythrocyte membrane in type 2 diabetes mellitus.Discoveries (Craiova, Romania) · 2016Review
- In Vitro and in Silico Analysis of α -Amylase Inhibitory Activity of Ethanolic Extract ofGlobal advances in integrative medicine and healthArticle
- Exploring AyuGenomics approach for understanding COVID-19 predisposition and progression.Journal of Ayurveda and integrative medicineReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple factors are involved in the development and progression of type 2 diabetes mellitus (DMII) to DMII with metabolic syndrome (MetS) and cardiovascular complications. To identify some of these factors, we aim to investigate the changes in erythrocyte membrane Na(+)/K(+)-ATPase activity, serum glucose, insulin, lipid profile, hemoglobin A1C (HbA1c), high-sensitivity C-reactive protein (hs-CRP), anthropometric measurements, and blood pressure in DMII with and without MetS. MATERIALS AND
methodsThis cross-sectional study comprised 155 male subjects distributed into three groups as healthy controls (50 non-DMII volunteers), Group I (50 DMII without MetS), and Group II (55 DMII with MetS). Fasting blood samples were taken for the measurement of glucose, insulin, HbA1c, hs-CRP and lipid profile. Na(+)/K(+)-ATPase activity was determined in erythrocyte ghost.
resultsNa(+)/K(+)-ATPase activity was significantly decreased in DMII groups compared with controls. No significant difference was shown in Na(+)/K(+)-ATPase activity between DMII groups. Total ATPase activity, total cholesterol and low-density lipoprotein-cholesterol levels were similar in the three groups. Levels of insulin, hs-CRP, triacylglycerols, systolic blood pressure, weight, waist and hip circumference, waist/hip ratio, and body mass index were significantly elevated and high-density lipoprotein-cholesterol significantly decreased only in Group II. Significant differences in serum glucose and hip circumference were seen between the groups. No significant differences in HbA1c levels were observed between DMII groups.
conclusionChanges in many of the measured risk factors that occurred only in Group II compared with controls and Group I may provide an explanation of how DMII progresses to DMII with MetS and future cardiovascular complications.
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