Evidence map›Paper›PMID 26664393›Full record

ArticleIranian journal of pharmaceutical research : IJPR2015

Characterization of Encapsulated Berberine in Yeast Cells of Saccharomyces cerevisiae.

Roshanak Salari, Omid Rajabi, Zahra Khashyarmanesh, Mohsen Fathi Najafi, BiBi Sedigheh Fazly Bazzaz

Abstract read
In one paragraph

Article in Iranian journal of pharmaceutical research : IJPR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Microencapsulation of Spent Coffee Extract WithinFoods (Basel, Switzerland) · 2025
    Article
  2. Review
  3. Review
  4. Article
  5. Investigation of the BestElectronic physician · 2017
    Article
  6. A Simple and Rapid Protocol for Producing Yeast Extract fromIranian journal of pharmaceutical research : IJPR · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Roshanak SalariDepartment of Drug and Food Control, School of Pharmacy, Mashhad University of Medical Sciences.
Omid RajabiDepartment of Drug and Food Control, School of Pharmacy, Mashhad University of Medical Sciences. ; Targetted Drug Delivery Research Centre, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Zahra KhashyarmaneshDepartment of Drug and Food Control, School of Pharmacy, Mashhad University of Medical Sciences.
Mohsen Fathi NajafiDepartment of Veterinary Research and Biotechnology, Razi Vaccine and Serum Research Institute, Mashhad, Iran.
BiBi Sedigheh Fazly BazzazDepartment of Drug and Food Control, School of Pharmacy, Mashhad University of Medical Sciences. ; Biotechnology Research Centre, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Berberine was loaded in yeast cells of Saccharomyces cerevisiaeas a novel pharmaceutical carrier to improve the treatment ofmany diseases. The yeast-encapsulated active materialsshowedhigh stability and bioavailability due to the enhanced solubility and sustained releasing. In this study, different characteristics of prepared berberine loaded yeast cells (loading capacity, release kinetic order, MIC and stability) were evaluatedby different analytical methods (fluorescence spectroscopy, HPLC and SEM).The loading capacity was about 78% ± 0.6%.Berberine release patterns of microcapsules happened in two different stages and followed by zero and first-order kinetic,respectively. About 99% of all active material released during 34 h. MIC was improved by berberine loaded microcapsules in comparison withberberine powder. The microcapsules were completely stable. Berberine loaded Sac. Cerevisiae could be considered as a favorite sustained release drug delivery system. The yeast would be applied as an efficient carrier to improve various properties of different active materials.

Indexed as

BerberinekineticMICmicroencapsulationyeast cells

Identifiers

PMID26664393
PMCPMC4673954

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.