Evidence map›Paper›PMID 26664381›Full record

ArticleIranian journal of pharmaceutical research : IJPR2015

Berberine chloride pretreatment exhibits neuroprotective effect against 6-hydroxydopamine-induced neuronal insult in rat.

Feraidoon Negahdar, Mehdi Mehdizadeh, Mohammad Taghi Joghataei, Mehrdad Roghani, Fereshteh Mehraeen, Ehsan Poorghayoomi

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Iranian journal of pharmaceutical research : IJPR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Berberine Alleviates AmyloidOxidative medicine and cellular longevity · 2019
    Article
  10. Berberine alleviates symptoms of anxiety by enhancing dopamine expression in rats with post-traumatic stress disorder.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2018
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Feraidoon NegahdarCellular and Molecular Research Center, Department of Anatomical Sciences, and Faculty of Advanced Technology, Iran University of Medical Sciences, Tehran, Iran.
Mehdi MehdizadehCellular and Molecular Research Center, Department of Anatomical Sciences, and Faculty of Advanced Technology, Iran University of Medical Sciences, Tehran, Iran.
Mohammad Taghi JoghataeiCellular and Molecular Research Center, Department of Anatomical Sciences, and Faculty of Advanced Technology, Iran University of Medical Sciences, Tehran, Iran.
Mehrdad RoghaniNeurophysiology Research Center, Shahed University, Tehran, Iran.
Fereshteh MehraeenCellular and Molecular Research Center, Department of Anatomical Sciences, and Faculty of Advanced Technology, Iran University of Medical Sciences, Tehran, Iran.
Ehsan PoorghayoomiCellular and Molecular Research Center, Department of Anatomical Sciences, and Faculty of Advanced Technology, Iran University of Medical Sciences, Tehran, Iran.
Shahed University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a rather common movement disorder as a result of the degeneration of dopaminergic neurons within the substantianigra. Current treatments for PD afford symptomatic relief with no prevention of disease progression. Due to the neuroprotective and anti-apoptotic potential of the isoquinoline alkaloid berberine (BBR), this study was conducted to assess whether BBR pretreatment could attenuate behavioral and neuronal derangement in 6-hydroxydopamine (6-OHDA)-induced model of PD in the rat. Unilateral intrastriatal 6-OHDA-lesioned rats received BBR at doses of 25 and/or 50 mg/kg (i.p.) three times at an interval of 24 h, started 2 days before the surgery. After 1 week, apomorphine caused significant contralateral rotations and a significant reduction in the number of Nissl-stained and tyrosine-hydroxylase (TH)-positive neurons on the left side of the substantianigra. BBR pretreatment at a dose of 50 mg/kg significantly reduced rotations and prevented loss of TH-positive neurons. These results indicate pre-lesion administration of BBR could protect against 6-OHDA toxicity and this may be of benefit besides other available therapies in PD.

Indexed as

6-hydroxydopamineBerberineParkinson’s diseaseTyrosine hydroxylase

Identifiers

PMID26664381
PMCPMC4673942
OpenAlexW1805478006

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.