Evidence map›Paper›PMID 26664330›Full record

ArticleInternational journal of MS care

Care Partners and Multiple Sclerosis: Differential Effect on Men and Women.

Tamara McKenzie, Mary Elizabeth Quig, Tuula Tyry, Ruth Ann Marrie, Gary Cutter, Edward Shearin, Kamau Johnson, James Simsarian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of MS care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Towards conceptual convergence: A systematic review of psychological resilience in family caregivers of persons living with chronic neurological conditions.Health expectations : an international journal of public participation in health care and health policy · 2022
    Pooled it
  2. Article
  3. Aspects of dignity in family caregivers of persons suffering from multiple sclerosis.International journal of qualitative studies on health and well-being · 2025
    Article
  4. Article
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  7. Observational
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  11. Review
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  15. Assessment of Caregiver Inventory for Rett Syndrome.Journal of autism and developmental disorders · 2017
    Article
  16. Multiple sclerosis in Canada 2011 to 2031: results of a microsimulation modelling study of epidemiological and economic impacts.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2017
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tamara McKenzieAmerican School of Professional Psychology, Argosy University, Washington, DC, USA (TM, ES, KJ); Neuropsychology Associates of Fairfax, Fairfax, VA, USA (MEQ); Department of Neurology, Georgetown University Medical Center, Washington, DC, USA (MEQ); Dignity Health, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA (TT); Departments of Medicine and Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada (RAM); Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA (GC); and Neurology Center of Fairfax, Fairfax, VA, USA (JS).
Mary Elizabeth QuigAmerican School of Professional Psychology, Argosy University, Washington, DC, USA (TM, ES, KJ); Neuropsychology Associates of Fairfax, Fairfax, VA, USA (MEQ); Department of Neurology, Georgetown University Medical Center, Washington, DC, USA (MEQ); Dignity Health, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA (TT); Departments of Medicine and Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada (RAM); Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA (GC); and Neurology Center of Fairfax, Fairfax, VA, USA (JS).
Tuula TyryAmerican School of Professional Psychology, Argosy University, Washington, DC, USA (TM, ES, KJ); Neuropsychology Associates of Fairfax, Fairfax, VA, USA (MEQ); Department of Neurology, Georgetown University Medical Center, Washington, DC, USA (MEQ); Dignity Health, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA (TT); Departments of Medicine and Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada (RAM); Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA (GC); and Neurology Center of Fairfax, Fairfax, VA, USA (JS).
Ruth Ann MarrieAmerican School of Professional Psychology, Argosy University, Washington, DC, USA (TM, ES, KJ); Neuropsychology Associates of Fairfax, Fairfax, VA, USA (MEQ); Department of Neurology, Georgetown University Medical Center, Washington, DC, USA (MEQ); Dignity Health, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA (TT); Departments of Medicine and Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada (RAM); Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA (GC); and Neurology Center of Fairfax, Fairfax, VA, USA (JS).
Gary CutterAmerican School of Professional Psychology, Argosy University, Washington, DC, USA (TM, ES, KJ); Neuropsychology Associates of Fairfax, Fairfax, VA, USA (MEQ); Department of Neurology, Georgetown University Medical Center, Washington, DC, USA (MEQ); Dignity Health, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA (TT); Departments of Medicine and Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada (RAM); Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA (GC); and Neurology Center of Fairfax, Fairfax, VA, USA (JS).
Edward ShearinAmerican School of Professional Psychology, Argosy University, Washington, DC, USA (TM, ES, KJ); Neuropsychology Associates of Fairfax, Fairfax, VA, USA (MEQ); Department of Neurology, Georgetown University Medical Center, Washington, DC, USA (MEQ); Dignity Health, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA (TT); Departments of Medicine and Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada (RAM); Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA (GC); and Neurology Center of Fairfax, Fairfax, VA, USA (JS).
Kamau JohnsonAmerican School of Professional Psychology, Argosy University, Washington, DC, USA (TM, ES, KJ); Neuropsychology Associates of Fairfax, Fairfax, VA, USA (MEQ); Department of Neurology, Georgetown University Medical Center, Washington, DC, USA (MEQ); Dignity Health, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA (TT); Departments of Medicine and Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada (RAM); Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA (GC); and Neurology Center of Fairfax, Fairfax, VA, USA (JS).
James SimsarianAmerican School of Professional Psychology, Argosy University, Washington, DC, USA (TM, ES, KJ); Neuropsychology Associates of Fairfax, Fairfax, VA, USA (MEQ); Department of Neurology, Georgetown University Medical Center, Washington, DC, USA (MEQ); Dignity Health, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA (TT); Departments of Medicine and Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada (RAM); Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA (GC); and Neurology Center of Fairfax, Fairfax, VA, USA (JS).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCaring for someone with multiple sclerosis (MS) can be a stressful experience that requires clinical attention. We investigated the impact of caregiver stress on the emotional well-being and physical health of the MS care partner using the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry.

methodsCare partners of NARCOMS participants were invited to complete an online questionnaire that captured demographic characteristics, health status, caregiver burden as measured by the Zarit Caregiver Burden Interview, and impact of caregiving on employment.

resultsOf 1446 care partners who agreed to participate, 1333 had complete data. Most were men (n = 825, 61.9%), with a mean (SD) age of 51.1 (11.2) years. The mean (SD) Zarit total score was 24.6 (15.1), placing the overall group in the mild caregiver burden range. Compared with male care partners, female care partners reported higher levels of burden and stress and more medication use for stress/anxiety and mood disorders. Male care partners were more likely to report physical concerns. Care partners of people with primary progressive MS reported greater perceived burden than did partners of people with secondary progressive MS and relapsing-remitting MS. More than 40% of care partners (559 of 1288) had missed work during the past year owing to caregiving responsibilities.

conclusionsCare partners of people with MS have substantial physical and psychological health concerns and experience an adverse impact on employment. Future research should evaluate how to mitigate the adverse effects of caregiving and evaluate positive aspects of the role.

Identifiers

PMID26664330
PMCPMC4673917

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.