ArticleIndian journal of psychological medicine
Correlates of Baclofen Effectiveness in Alcohol Dependence.
Article in Indian journal of psychological medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Alcohol use disorder research in India: An update.Indian journal of psychiatry · 2024Review
- The use of off-label medications in substance abuse treatment programs.Substance abuse · 2020Article
- Brain Functional Magnetic Resonance Imaging Cue-reactivity Can Predict Baclofen Response in Alcohol Use Disorders.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2018Article
- A Review of the Potential Mechanisms of Action of Baclofen in Alcohol Use Disorder.Frontiers in psychiatry · 2018Review
- Tailored-Dose Baclofen in the Management of Alcoholism: A Retrospective Study of 144 Outpatients Followed for 3 Years in a French General Practice.Frontiers in psychiatry · 2018Article
- Baclofen in the Treatment of Patients With Alcohol Use Disorder and Other Mental Health Disorders.Frontiers in psychiatry · 2018Review
- Pharmacotherapy for relapse prevention of alcohol use disorder in the Indian setting: A systematic review.Industrial psychiatry journalReview
- A comparative study on the safety and efficacy of naltrexone versus baclofen versus acamprosate in the management of alcohol dependence.Indian journal of psychiatryArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alcohol dependence is a global concern. Baclofen has shown promise as an anti-craving agent but its efficiency remains to be settled. We reviewed 549 male cases diagnosed with alcohol dependence who received Acamprosate (201) or Baclofen (348). 'Time to first drink' was compared between two groups and multiple regression analysis was done in baclofen group to identify correlates of effectiveness. There was a significant difference in outcome measure between Baclofen (M = 4.44, SD = 3.75) and Acamprosate group (M = 3.73, SD = 2.19); t (547) = 2.45, P = 0.01. Initial regression analysis with six predictor variables (average daily alcohol units, current age, age at onset of dependence, family history, duration of dependence and dose of baclofen in mg/day) showed significant correlation of outcome variable with only two predictor variables - dose of baclofen and average daily intake. Using the hierarchical method it was found that 'dose of baclofen' and 'average alcohol intake' explain a significant amount of variance in 'time to first drink'. [F (1, 345) = 182.8, P < 0.001, R2 = 0.52, R2adjusted = 0.51]. This information can be used to select patients in long term longitudinal studies and may explain variable results seen in clinical trials of baclofen done earlier.
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