Evidence map›Paper›PMID 26664042›Full record

ReviewClinical ophthalmology (Auckland, N.Z.)2015

Does autoimmunity against thyroglobulin play a role in the pathogenesis of Graves' ophthalmopathy: a review.

Thayalini Shanmuganathan, Christian Girgis, Hooshang Lahooti, Bernard Champion, Jack R Wall

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical ophthalmology (Auckland, N.Z.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. MicroRNAs and Autoimmune-Mediated Eye Diseases.Frontiers in cell and developmental biology · 2020
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Thayalini ShanmuganathanDepartment of Medicine, Nepean Clinical School, Nepean Hospital, The University of Sydney, Sydney, NSW, Australia.
Christian GirgisDepartment of Medicine, Westmead Millennium Institute, The University of Sydney, Sydney, NSW, Australia.
Hooshang LahootiDepartment of Medicine, Nepean Clinical School, Nepean Hospital, The University of Sydney, Sydney, NSW, Australia.
Bernard ChampionDepartment of Medicine, Nepean Clinical School, Nepean Hospital, The University of Sydney, Sydney, NSW, Australia.
Jack R WallDepartment of Medicine, Nepean Clinical School, Nepean Hospital, The University of Sydney, Sydney, NSW, Australia.
University of Sydney · AUNepean Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While most authors believe that autoimmunity against the TSH receptor expressed in the orbital connective tissue cells is the main reaction that leads to the development of ophthalmopathy in patients with Graves' hyperthyroidism, an older hypothesis that deserves fresh consideration is based on the notion that thyroglobulin (Tg) in the thyroid gland passes in a retrograde fashion to the orbit where it is recognized by Tg autoantibodies, leading to inflammation. Here, we review new evidence that supports a role of Tg and propose a new hypothesis based on the notion that Tg is targeted in the orbit leading to a complex cascade of reactions that leads to Graves' ophthalmopathy.

Indexed as

autoantibodiesGraves’ diseaselymphocytesophthalmopathythyroglobulinthyroid peroxidaseTSH receptor

Identifiers

PMID26664042
PMCPMC4671807
OpenAlexW2194683959

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.