ArticlePharmacognosy magazine2015
Selectivity of Pinus sylvestris extract and essential oil to estrogen-insensitive breast cancer cells Pinus sylvestris against cancer cells.
Article in Pharmacognosy magazine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Integrated Chemical, Computational, and Cellular Profiling of a Dual-Oil Melanoma Formulation: An Exploratory Life-Science Study.Life (Basel, Switzerland) · 2026Article
- Chemical Profiling, Molecular Docking, and Mechanistic Anticancer Activity ofMolecules (Basel, Switzerland) · 2026Article
- Antimicrobial and Antioxidant Activity of Essential Oils from SelectedAntibiotics (Basel, Switzerland) · 2025Review
- An Overview of the Bioactivity of Spontaneous Medicinal Plants Suitable for the Improvement of Lung Cancer Therapies.Pharmaceutics · 2025Review
- Ethnopharmacology ofFrontiers in pharmacology · 2025Review
- Chemical Content and Cytotoxic Activity on Various Cancer Cell Lines of Chaga (Pharmaceuticals (Basel, Switzerland) · 2024Article
- Antioxidant Activity of Essential Oils from Pinaceae Species.Antioxidants (Basel, Switzerland) · 2024Review
- Application of Baltic Pine (Plants (Basel, Switzerland) · 2023Article
- Chemical Investigation and Dose-Response Phytotoxic Effect of Essential Oils from Two Gymnosperm Species (Plants (Basel, Switzerland) · 2022Article
- The Phytochemical Profile and Anticancer Activity ofPlants (Basel, Switzerland) · 2022Article
- Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models.Cell death discovery · 2021Article
- Article
- Chemical Composition and Antimicrobial Activity of Essential Oils from the Aerial Parts ofMolecules (Basel, Switzerland) · 2019Article
- Pine needle oil induces G2/M arrest of HepG2 cells by activating the ATM pathway.Experimental and therapeutic medicine · 2018Article
- Lepidiumuridine A: A New Natural Uridine Derivative as a Phytoestrogen Isolated from the Seeds ofEvidence-based complementary and alternative medicine : eCAM · 2018Article
- Antibacterial activities of chemical constituents from the aerial parts of Hedyotis pilulifera.Pharmaceutical biology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSo far, the anticancer action of pine tree extracts has mainly been shown for the species distributed widely around the Asian countries.
objectiveTherefore, this study was performed to examine the potential cytotoxicity of Scots pine (Pinus sylvestris L.) native also to the European region and growing widely in Estonia. MATERIALS AND
methodsThe cytotoxic activity of methanol extract and essential oil of Scots pine needles was determined by sulforhodamine B assay in different human cancer cell lines.
resultsThis needle extract was found to suppress the viability of several human cancer cell lines showing some selectivity to estrogen receptor negative breast cancer cells, MDA-MB-231(half maximal inhibitory concentration [IC50] 35 μg/ml) in comparison with estrogen receptor-positive breast cancer cells, MCF-7 (IC50 86 μg/ml). It is the strongest cytotoxic effect at all measured, thus far for the needles and leaves extracts derived from various pine species, and is also the first study comparing the anticancer effects of pine tree extracts on molecularly different human breast cancer cells. The essential oil showed the stronger cytotoxic effect to both negative and positive breast cancer cell lines (both IC50 29 μg/ml) than pine extract (IC50 42 and 80 μg/ml, respectively).
conclusionThe data from this report indicate that Scots pine needles extract and essential oil exhibits some potential as chemopreventive or chemotherapeutic agent for mammary tumors unresponsive to endocrine treatment.
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