ArticlePharmacognosy magazine2015
Herbal therapy: A review of emerging pharmacological tools in the management of diabetes mellitus in Africa.
Article in Pharmacognosy magazine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- A Beneficial Role of Rooibos in Diabetes Mellitus: A Systematic Review and Meta-Analysis.Molecules (Basel, Switzerland) · 2018Pooled it
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- Trends in diabetes care with special emphasis to medicinal plants: Advancement and treatment.Biocatalysis and agricultural biotechnology · 2021Review
- Lychee Seed as a Potential Hypoglycemic Agent, and Exploration of its Underlying Mechanisms.Frontiers in pharmacology · 2021Review
- In Vitro Antioxidant Activities of Methanolic Extracts ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
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- Antihyperglycemic Activity ofPharmacognosy magazine · 2017Article
- In Vivo Hypoglycemic Effect of Kigelia africana (Lam): Studies With Alloxan-Induced Diabetic Mice.Journal of evidence-based integrative medicineArticle
- Insulin Plant (Pharmacognosy researchArticle
- Preclinical Toxicological Evaluation of IDM01: The Botanical Composition of 4-Hydroxyisoleucine- and Trigonelline-based Standardized Fenugreek Seed Extract.Pharmacognosy researchArticle
- Antidiabetic Effects of Aqueous and Dichloromethane/Methanol Stem Bark Extracts ofPharmacognosy researchArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetes mellitus is a chronic physiological glucose metabolic disorder. It has affected millions of people all over the world thereby having a significant impact on quality of life. The management of diabetes includes both nonpharmacological and conventional interventions. Drawbacks in conventional therapy have led to seeking alternative therapy in herbal medicine. Therefore, the need to review, elucidate and classify their mode of action in therapy for diabetes disease arises. MATERIALS AND
methodsComprehensive literature reports were used to review all conventional agents and herbal therapy used in the management of diabetes. An online database search was conducted for medicinal plants of African origin that have been investigated for their antidiabetic therapeutic potentials.
resultsThe results showed that of the documented sixty five plants used, fourteen inhibit intestinal absorption of glucose, three exhibit insulin-mimetic properties, seventeen stimulate insulin secretion from pancreatic beta cells, twelve enhance peripheral glucose uptake, one promotes regeneration of beta-cell of islets of Langerhans, thirteen ameliorate oxidative stress and twenty induces hypoglycemic effect (mode of action is still obscure). Thirteen of these plants have a duplicate mode of actions while one of them has three modes of actions. These agents have a similar mechanism of action as the conventional drugs.
conclusionIn conclusion, antidiabetic activities of these plants are well established; however, the molecular modulation remains unknown. It is envisaged that the use of herbal therapy will promote good health and improve the status of diabetic patients.
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