ArticleDiabetes/metabolism research and reviews2016
Arsenic exposure is associated with diminished insulin sensitivity in non-diabetic Amish adults.
Article in Diabetes/metabolism research and reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Low-level exposure to arsenic in drinking water and risk of type 2 diabetes: a systematic review and meta-analysis.European journal of epidemiology · 2026Pooled it
- Metals in the human liver: An underappreciated risk factor of hepatic insulin resistance and associated pathophysiology.Environmental pollution (Barking, Essex : 1987) · 2025Review
- Arsenic exposure and measures of glucose tolerance in Bangladeshi adults: A cross-sectional study.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Glycemic Changes Related to Arsenic Exposure: An Overview of Animal and Human Studies.Nutrients · 2024Review
- Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024Article
- Arsenic exposure during pregnancy and postpartum maternal glucose tolerance: evidence from Bangladesh.Environmental health : a global access science source · 2022Article
- Is Arsenic Exposure a Risk Factor for Metabolic Syndrome? A Review of the Potential Mechanisms.Frontiers in endocrinology · 2022Review
- Associations between rice consumption, arsenic metabolism, and insulin resistance in adults without diabetes.International journal of hygiene and environmental health · 2021Article
- Total Urinary Arsenic and Inorganic Arsenic Concentrations and Birth Outcomes in Pregnant Women of Tacna, Peru: A Cross-Sectional Study.Exposure and health · 2021Article
- Urinary metal mixtures and longitudinal changes in glucose homeostasis: The Study of Women's Health Across the Nation (SWAN).Environment international · 2020Article
- Non-monotonic dose-response effects of arsenic on glucose metabolism.Toxicology and applied pharmacology · 2019Article
- Higher risk of hyperglycemia with greater susceptibility in females in chronic arsenic-exposed individuals in Bangladesh.The Science of the total environment · 2019Article
- Arsenic exposure and risk of nonalcoholic fatty liver disease (NAFLD) among U.S. adolescents and adults: an association modified by race/ethnicity, NHANES 2005-2014.Environmental health : a global access science source · 2018Article
- Association of type 1 diabetes and concentrations of drinking water components in Newfoundland and Labrador, Canada.BMJ open diabetes research & care · 2018Article
- Association of Low-Moderate Arsenic Exposure and Arsenic Metabolism with Incident Diabetes and Insulin Resistance in the Strong Heart Family Study.Environmental health perspectives · 2017Article
- Exposures to arsenite and methylarsonite produce insulin resistance and impair insulin-dependent glycogen metabolism in hepatocytes.Archives of toxicology · 2017Article
- Investigation of Health Effects According to the Exposure of Low Concentration Arsenic Contaminated Ground Water.International journal of environmental research and public health · 2017Article
- Genetic and epigenetic mechanisms underlying arsenic-associated diabetes mellitus: a perspective of the current evidence.Epigenomics · 2017Review
- Association of arsenobetaine with beta-cell function assessed by homeostasis model assessment (HOMA) in nondiabetic Koreans: data from the fourth Korea National Health and Nutrition Examination Survey (KNHANES) 2008-2009.Annals of occupational and environmental medicine · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSubstantial evidence supports an association between diabetes and arsenic at high exposure levels, but results are mixed at low exposure levels. The aetiology of diabetes involves insulin resistance and β-cell dysfunction. However, only a few epidemiologic studies have examined measures of insulin resistance and β-cell function in relation to arsenic exposure, and no studies have tested for associations with the oral glucose tolerance test (OGTT). We examined the association between urinary total arsenic and OGTT-based markers of insulin sensitivity and β-cell function.
methodsWe studied 221 non-diabetic adults (mean age = 52.5 years) from the Amish Family Diabetes Study. We computed OGTT-based validated measures of insulin sensitivity and β-cell function. Generalized estimating equations accounting for sibship were used to estimate associations.
resultsAfter adjusting for age, sex, waist-to-hip ratio and urinary creatinine, an interquartile range increase in urinary total arsenic (6.24 µg/L) was significantly, inversely associated with two insulin sensitivity measures (Stumvoll metabolic clearance rate = -0.23 mg/(kg min), (95% CI: -0.38, -0.089), p = 0.0015; Stumvoll insulin sensitivity index = -0.0029 µmol/(kg min pM), (95% CI: -0.0047, -0.0011), p = 0.0015). Urinary total arsenic was also significantly associated with higher fasting glucose levels (0.57 mg/dL (95% CI: 0.06, 1.09) per interquartile range increase, p = 0.029). No significant associations were found between urinary total arsenic and β-cell function measures.
conclusionsThis preliminary study found that urinary total arsenic was associated with insulin sensitivity but not β-cell function measures, suggesting that low-level arsenic exposure may influence diabetes risk through impairing insulin sensitivity. Copyright © 2015 John Wiley & Sons, Ltd.
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