ArticleJournal of evolutionary biology2016
Fitness effects of new mutations in Chlamydomonas reinhardtii across two stress gradients.
Article in Journal of evolutionary biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Are mutations usually deleterious? A perspective on the fitness effects of mutation accumulation.Evolutionary ecology · 2022Article
- Precise measurement of the fitness effects of spontaneous mutations by droplet digital PCR in Burkholderia cenocepacia.Genetics · 2021Article
- Quantifying the Evolutionary Constraints and Potential of Hepatitis C Virus NS5A Protein.mSystems · 2021Article
- The effects of individual nonheritable variation on fitness estimation and coexistence.Ecology and evolution · 2019Article
- Inferring the distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii.PLoS biology · 2019Article
- Quantifying natural seasonal variation in mutation parameters with mutation accumulation lines.Ecology and evolution · 2018Article
- Low-phosphate-selected Auxenochlorella protothecoides redirects phosphate to essential pathways while producing more biomass.PloS one · 2018Article
- Fitness change in relation to mutation number in spontaneous mutation accumulation lines of Chlamydomonas reinhardtii.Evolution; international journal of organic evolution · 2017Article
- The Fitness Effects of Spontaneous Mutations Nearly Unseen by Selection in a Bacterium with Multiple Chromosomes.Genetics · 2016Article
- Fitness Effects of Spontaneous Mutations in Picoeukaryotic Marine Green Algae.G3 (Bethesda, Md.) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most spontaneous mutations affecting fitness are likely to be deleterious, but the strength of selection acting on them might be impacted by environmental stress. Such stress-dependent selection could expose hidden genetic variation, which in turn might increase the adaptive potential of stressed populations. On the other hand, this variation might represent a genetic load and thus lead to population extinction under stress. Previous studies to determine the link between stress and mutational effects on fitness, however, have produced inconsistent results. Here, we determined the net change in fitness in 29 genotypes of the green algae Chlamydomonas reinhardtii that accumulated mutations in the near absence of selection for approximately 1000 generations across two stress gradients, increasing NaCl and decreasing phosphate. We found mutational effects to be magnified under extremely stressful conditions, but such effects were specific both to the type of stress and to the genetic background. The detection of stress-dependent fitness effects of mutations depended on accurately scaling relative fitness measures by generation times, thus offering an explanation for the inconsistencies among previous studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.