Evidence map›Paper›PMID 26663175›Full record

ArticleAdvances in experimental medicine and biology2015

Exploiting microRNA Specificity and Selectivity: Paving a Sustainable Path Towards Precision Medicine.

Gaetano Santulli

Abstract read
In one paragraph

Article in Advances in experimental medicine and biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Mitochondrial microRNAs Are Dysregulated in Patients with Fabry Disease.The Journal of pharmacology and experimental therapeutics · 2023
    Article
  3. Article
  4. Article
  5. MicroRNAs and Endothelial (Dys) Function.Journal of cellular physiology · 2016
    Review
  6. Novel Biomarkers and Treatments of Cardiac Diseases.BioMed research international · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Gaetano SantulliColumbia University Medical Center, New York, NY, USA. gsantulli001@gmail.com.

Funding

Targeting intracellular calcium leak as novel therapy for diabetesK99DK107895 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SANTULLI, GAETANO · 2015 to 2016
$176k
NIDDK NIH HHS 1K99DK107895NIDDK NIH HHS K99 DK107895
6 · The paper itself

Abstract

In his State of the Union address before both chambers of the US Congress, President Barack Obama called for increased investment in US infrastructure and research and announced the launch of a new Precision Medicine Initiative, aiming to accelerate biomedical discovery. Due to their well-established selectivity and specificity, microRNAs can represent a useful tool, both in diagnosis and therapy, in forging the path towards the achievement of precision medicine. This introductory chapter represents a guide for the Reader in examining the functional roles of microRNAs in the most diverse aspects of clinical practice, which will be explored in this third volume of the microRNA trilogy.

Indexed as

Biomedical ResearchDiseaseEarly DiagnosisGene Expression RegulationHumansMicroRNAsPrecision MedicineReproducibility of ResultsSensitivity and SpecificityMicroRNAsInitiativemiRNAPharmacogeneticsPharmacogenomicsPrecision medicineSelectivitySpecificity

Identifiers

PMID26663175
PMCPMC4871240

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.