Evidence map›Paper›PMID 26662808›Full record

ArticleEuropean child & adolescent psychiatry2016

A reply to Wang T, Shan L, Du L, Feng J, Xu Z, Staal WG, Jia F. Serum concentration of 25-hydroxyvitamin D in autism spectrum disorder: a systematic review and meta-analysis. Eur Child Adolesc Psychiatry. 2015; doi: 10.1007/s00787-015-0786-1.

Keith Fluegge

Abstract readLetterComment
PubMed Publisher
In one paragraph

Article in European child & adolescent psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Keith FlueggeInstitute of Health and Environmental Research, Cleveland, OH, 44118, USA. keithfluegge@iher.org.
Cleveland Research (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The author of this correspondence has recently published findings of an ecological investigation wherein herbicide use was proposed as an instrumental variable that predicts healthcare utilization among subjects with severe ADHD impairment via individual exposure to nitrous oxide (N2O) emissions. Vitamin D deficiency, a possible risk factor for autism spectrum disorders (ASD) as discussed by Wang et al., may be a homeostatic response to increasing chronic environmental N2O exposures. The author explains how deficient and insufficient states of vitamin D may promote vagal withdrawal and tolerance to increasing opioid exposures in the environment and how these characteristics are particularly relevant in neurodevelopmental disorders, like ASD and ADHD.

Indexed as

Autism Spectrum DisorderVitamin D DeficiencyChildChild PsychiatryConduct DisorderHumansRisk FactorsAutismNitrous oxideVitamin D deficiency

Identifiers

PMID26662808
OpenAlexW2190372604

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.