ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016
The MSHA strain of Pseudomonas aeruginosa (PA-MSHA) inhibits gastric carcinoma progression by inducing M1 macrophage polarization.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Intratumoral injection of R848 and poly(I:C) synergistically promoted antitumor immune responses by reprogramming macrophage polarization and activating DCs in lung cancer.Clinical and experimental immunology · 2025Article
- Lung microbiome alterations correlate with immune imbalance in non-small cell lung cancer.Frontiers in immunology · 2025Article
- PA-MSHA exerts potent activity against cetuximab-resistant colorectal cancer through the miR-7-5p/Akt3/Wnt-β-catenin pathway.Translational cancer research · 2024Article
- Trends in Anti-Tumor Effects ofCancers · 2024Review
- Tumour-associated macrophages in gastric cancer: From function and mechanism to application.Clinical and translational medicine · 2023Review
- NeoadjuvantAnnals of translational medicine · 2023Article
- PA-MSHA induces inflamed tumor microenvironment and sensitizes tumor to anti-PD-1 therapy.Cell death & disease · 2022Article
- Review
- NF-κB in Cancer Immunity: Friend or Foe?Cells · 2021Review
- Tumor-Associated Macrophages: Protumoral Macrophages in Inflammatory Tumor Microenvironment.Advanced pharmaceutical bulletin · 2020Review
- Tumor-Associated Macrophages (TAMs): A Critical Activator In Ovarian Cancer Metastasis.OncoTargets and therapy · 2019Review
- Nanoparticles Targeting Macrophages as Potential Clinical Therapeutic Agents Against Cancer and Inflammation.Frontiers in immunology · 2019Review
- Molecular Repolarisation of Tumour-Associated Macrophages.Molecules (Basel, Switzerland) · 2018Review
- Redirecting tumor-associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapy.Oncotarget · 2017Review
- PA-MSHA induces apoptosis and suppresses metastasis by tumor associated macrophages in bladder cancer cells.Cancer cell international · 2017Article
- Article
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Authors and funding
8 authors.
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Abstract
Macrophages play crucial roles in promoting tumor development and progression. In the present study, we found that the mannose-sensitive hemagglutination pilus strain of Pseudomonas aeruginosa (PA-MSHA) was efficient in inducing M1 macrophage polarization. PA-MSHA treatment increases expression of M1-related cytokines and promotes activation of murine peritoneal macrophages (MPM). Interestingly, PA-MSHA inhibits cell proliferation and migration and induces the apoptosis of gastric carcinoma cells. These effects of PA-MSHA on M1 polarization were associated with activation of NF-κB expression. Thus, inducing polarization of M1 by PA-MSHA may be one potential strategy for inhibiting gastric carcinoma progression in mice.
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