Evidence map›Paper›PMID 26662625›Full record

ArticleMammalian genome : official journal of the International Mammalian Genome Society2016

Novel genetic tools facilitate the study of cortical neuron migration.

Megan Cionni, Chelsea Menke, Rolf W Stottmann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Megan CionniDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., MLC 7016, Cincinnati, OH, 45229, USA.
Chelsea MenkeDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., MLC 7016, Cincinnati, OH, 45229, USA.
Rolf W StottmannDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., MLC 7016, Cincinnati, OH, 45229, USA. rolf.stottmann@cchmc.org.
Cincinnati Children's Hospital Medical Center · US

Funding

High-throughput targeted mutagenesis of mouse stem cell linesU01HG004080 · NHGRI · CHILDREN'S HOSPITAL & RES CTR AT OAKLAND · PI DE JONG, PIETER J. · 2006 to 2010
$28.1M
Production of Targeted Null Mutations for 10,000 Genes in C57BL/6 ES CellsU01HG004085 · NHGRI · REGENERON PHARMACEUTICALS, INC. · PI VALENZUELA, DAVID MANUEL · 2006 to 2010
$25.3M
UCD KOMP PROJECT REPOSITORYU42RR024244 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LLOYD, KC KENT · 2007 to 2010
$7.9M
Forward Genetic Analysis of Congenital Defects in Cortical Circuits and StructureR01NS085023 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI STOTTMANN, ROLF W · 2014 to 2018
$2.3M
NCRR NIH HHS U42 RR024244NCRR NIH HHS U42RR024244NHGRI NIH HHS U01 HG004080NHGRI NIH HHS U01HG004080NHGRI NIH HHS U01 HG004085NINDS NIH HHS R01 NS085023NINDS NIH HHS R01NS085023
6 · The paper itself

Abstract

Key facets of mammalian forebrain cortical development include the radial migration of projection neurons and subsequent cellular differentiation into layer-specific subtypes. Inappropriate regulation of these processes can lead to a number of congenital brain defects in both mouse and human, including lissencephaly and intellectual disability. The genes regulating these processes are still not all identified, suggesting genetic analyses will continue to be a powerful tool in mechanistically studying the development of the cerebral cortex. Reelin is a molecule which we have understood to be critical for proper cortical development for many years. The precise mechanism of Reelin, however, is not fully understood. To address both of these unresolved issues, we report here the creation of a novel conditional allele of the Reelin gene and showcase the use of an Etv1-GFP transgenic line highlighting a subpopulation of the cortex: layer V pyramidal neurons. Together, these represent genetic tools which may facilitate the study of cortical development in a number of different ways.

Indexed as

Founder EffectMice, TransgenicAllelesAnimalsCell Adhesion Molecules, NeuronalCell MovementCerebellumCerebral CortexCrosses, GeneticDNA-Binding ProteinsEmbryonic Stem CellsExtracellular Matrix ProteinsFemaleGene ExpressionGreen Fluorescent ProteinsHippocampusCell Adhesion Molecules, NeuronalDNA-Binding ProteinsEtv1 protein, mouseExtracellular Matrix ProteinsGreen Fluorescent ProteinsNerve Tissue ProteinsRecombinant Fusion ProteinsReelin ProteinRELN protein, humanReln protein, mouseSerine EndopeptidasesTranscription Factors

Identifiers

PMID26662625
PMCPMC4732900
OpenAlexW2192230146

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.