ArticlePlant physiology2016
Identification of a Stelar-Localized Transport Protein That Facilitates Root-to-Shoot Transfer of Chloride in Arabidopsis.
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Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47citing papers in PubMed
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47 citing papers in PubMed, 126 citations in OpenAlex.
- The ZAT7-OTU11-DOA9-CYS13 module enhances salt resistance by suppressing NPF2.4-mediated chloride transport in Arabidopsis.Plant communications · 2026Article
- The Dual-Function of CtrNAC019-CtrNPF2.1 Module in Salt Tolerance and Nitrogen Use Efficiency Via Enhancing Vacuolar Chloride Sequestration and Nitrate Efflux in Citrus trifoliata.Plant biotechnology journal · 2026Article
- Functional characterization of NRT1/PTR FAMILY transporters: looking for a needle in a haystack.The New phytologist · 2026Review
- PcNPF2.7 from the XerophyteBiology · 2025Article
- Expression of the grapevine anion transporter ALMT2 in Arabidopsis roots decreases the shoot Cl-/NO3- ratio under salt stress.Journal of experimental botany · 2025Article
- Genome-wide identification of key genes related to chloride ion (ClBMC genomics · 2025Article
- Root-specific expression ofHorticulture research · 2025Article
- Salinity survival: molecular mechanisms and adaptive strategies in plants.Frontiers in plant science · 2025Review
- Chloride transport and homeostasis in plants.Quantitative plant biology · 2025Review
- Fine-root and leaf acquisitive traits decoupled from chloride accumulation in reflecting the differential salinity tolerance amongFrontiers in plant science · 2024Article
- Ion Changes and Signaling under Salt Stress in Wheat and Other Important Crops.Plants (Basel, Switzerland) · 2023Review
- MaizeInternational journal of molecular sciences · 2023Article
- Time series single-cell transcriptional atlases reveal cell fate differentiation driven by light in Arabidopsis seedlings.Nature plants · 2023Article
- Genome-wide identification and expression analysis of the NRT genes in Ginkgo biloba under nitrate treatment reveal the potential roles during calluses browning.BMC genomics · 2023Article
- Genome-Wide Identification and Expression Analysis ofPlants (Basel, Switzerland) · 2023Article
- Sustaining nitrogen dynamics: A critical aspect for improving salt tolerance in plants.Frontiers in plant science · 2023Review
- Identification and Expression Analysis of theInternational journal of molecular sciences · 2022Article
- Silicate Inhibits the Cytosolic Influx of Chloride in Protoplasts of Wheat and Affects the Chloride Transporters,Plants (Basel, Switzerland) · 2022Article
- Concept of Fluorescent Transport Activity Biosensor for the Characterization of the Arabidopsis NPF1.3 Activity of Nitrate.Sensors (Basel, Switzerland) · 2022Article
- Genome-wide identification and characterization of NPF family reveals NtNPF6.13 involving in salt stress inFrontiers in plant science · 2022Article
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Authors and funding
14 authors at 3 institutions in 4 countries.
Bo LiAustralian Centre for Plant Functional Genomics (B.L., J.Q., U.B., M.H., A.E., D.J., M.T., S.J.R.), School of Agriculture, Food, and Wine (B.L., C.B., J.Q., U.B., M.H., A.E., G.M.M., D.J., S.W.H., M.T., M.G., S.J.R.), and ARC Centre of Excellence in Plant Energy Biology (C.B., J.Q., S.W.H., M.G.), University of Adelaide, SA 5064, Australia;Centre for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia (B.L., M.T.);School of BioSciences, University of Melbourne, Parkville, Vic 3010, Australia (A.A.T.J.); and Centre for Genomics and Systems Biology, New York University, New York 10003 (K.D.B.).
Caitlin ByrtAustralian Centre for Plant Functional Genomics (B.L., J.Q., U.B., M.H., A.E., D.J., M.T., S.J.R.), School of Agriculture, Food, and Wine (B.L., C.B., J.Q., U.B., M.H., A.E., G.M.M., D.J., S.W.H., M.T., M.G., S.J.R.), and ARC Centre of Excellence in Plant Energy Biology (C.B., J.Q., S.W.H., M.G.), University of Adelaide, SA 5064, Australia;Centre for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia (B.L., M.T.);School of BioSciences, University of Melbourne, Parkville, Vic 3010, Australia (A.A.T.J.); and Centre for Genomics and Systems Biology, New York University, New York 10003 (K.D.B.).ORCID http://orcid.org/0000-0001-8549-2873
Jiaen QiuAustralian Centre for Plant Functional Genomics (B.L., J.Q., U.B., M.H., A.E., D.J., M.T., S.J.R.), School of Agriculture, Food, and Wine (B.L., C.B., J.Q., U.B., M.H., A.E., G.M.M., D.J., S.W.H., M.T., M.G., S.J.R.), and ARC Centre of Excellence in Plant Energy Biology (C.B., J.Q., S.W.H., M.G.), University of Adelaide, SA 5064, Australia;Centre for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia (B.L., M.T.);School of BioSciences, University of Melbourne, Parkville, Vic 3010, Australia (A.A.T.J.); and Centre for Genomics and Systems Biology, New York University, New York 10003 (K.D.B.).ORCID http://orcid.org/0000-0001-9220-4219
Ute BaumannAustralian Centre for Plant Functional Genomics (B.L., J.Q., U.B., M.H., A.E., D.J., M.T., S.J.R.), School of Agriculture, Food, and Wine (B.L., C.B., J.Q., U.B., M.H., A.E., G.M.M., D.J., S.W.H., M.T., M.G., S.J.R.), and ARC Centre of Excellence in Plant Energy Biology (C.B., J.Q., S.W.H., M.G.), University of Adelaide, SA 5064, Australia;Centre for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia (B.L., M.T.);School of BioSciences, University of Melbourne, Parkville, Vic 3010, Australia (A.A.T.J.); and Centre for Genomics and Systems Biology, New York University, New York 10003 (K.D.B.).
Maria HrmovaAustralian Centre for Plant Functional Genomics (B.L., J.Q., U.B., M.H., A.E., D.J., M.T., S.J.R.), School of Agriculture, Food, and Wine (B.L., C.B., J.Q., U.B., M.H., A.E., G.M.M., D.J., S.W.H., M.T., M.G., S.J.R.), and ARC Centre of Excellence in Plant Energy Biology (C.B., J.Q., S.W.H., M.G.), University of Adelaide, SA 5064, Australia;Centre for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia (B.L., M.T.);School of BioSciences, University of Melbourne, Parkville, Vic 3010, Australia (A.A.T.J.); and Centre for Genomics and Systems Biology, New York University, New York 10003 (K.D.B.).
Aurelie EvrardAustralian Centre for Plant Functional Genomics (B.L., J.Q., U.B., M.H., A.E., D.J., M.T., S.J.R.), School of Agriculture, Food, and Wine (B.L., C.B., J.Q., U.B., M.H., A.E., G.M.M., D.J., S.W.H., M.T., M.G., S.J.R.), and ARC Centre of Excellence in Plant Energy Biology (C.B., J.Q., S.W.H., M.G.), University of Adelaide, SA 5064, Australia;Centre for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia (B.L., M.T.);School of BioSciences, University of Melbourne, Parkville, Vic 3010, Australia (A.A.T.J.); and Centre for Genomics and Systems Biology, New York University, New York 10003 (K.D.B.).
Alexander A T JohnsonAustralian Centre for Plant Functional Genomics (B.L., J.Q., U.B., M.H., A.E., D.J., M.T., S.J.R.), School of Agriculture, Food, and Wine (B.L., C.B., J.Q., U.B., M.H., A.E., G.M.M., D.J., S.W.H., M.T., M.G., S.J.R.), and ARC Centre of Excellence in Plant Energy Biology (C.B., J.Q., S.W.H., M.G.), University of Adelaide, SA 5064, Australia;Centre for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia (B.L., M.T.);School of BioSciences, University of Melbourne, Parkville, Vic 3010, Australia (A.A.T.J.); and Centre for Genomics and Systems Biology, New York University, New York 10003 (K.D.B.).
Kenneth D BirnbaumAustralian Centre for Plant Functional Genomics (B.L., J.Q., U.B., M.H., A.E., D.J., M.T., S.J.R.), School of Agriculture, Food, and Wine (B.L., C.B., J.Q., U.B., M.H., A.E., G.M.M., D.J., S.W.H., M.T., M.G., S.J.R.), and ARC Centre of Excellence in Plant Energy Biology (C.B., J.Q., S.W.H., M.G.), University of Adelaide, SA 5064, Australia;Centre for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia (B.L., M.T.);School of BioSciences, University of Melbourne, Parkville, Vic 3010, Australia (A.A.T.J.); and Centre for Genomics and Systems Biology, New York University, New York 10003 (K.D.B.).
Gwenda M MayoAustralian Centre for Plant Functional Genomics (B.L., J.Q., U.B., M.H., A.E., D.J., M.T., S.J.R.), School of Agriculture, Food, and Wine (B.L., C.B., J.Q., U.B., M.H., A.E., G.M.M., D.J., S.W.H., M.T., M.G., S.J.R.), and ARC Centre of Excellence in Plant Energy Biology (C.B., J.Q., S.W.H., M.G.), University of Adelaide, SA 5064, Australia;Centre for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia (B.L., M.T.);School of BioSciences, University of Melbourne, Parkville, Vic 3010, Australia (A.A.T.J.); and Centre for Genomics and Systems Biology, New York University, New York 10003 (K.D.B.).
Deepa JhaAustralian Centre for Plant Functional Genomics (B.L., J.Q., U.B., M.H., A.E., D.J., M.T., S.J.R.), School of Agriculture, Food, and Wine (B.L., C.B., J.Q., U.B., M.H., A.E., G.M.M., D.J., S.W.H., M.T., M.G., S.J.R.), and ARC Centre of Excellence in Plant Energy Biology (C.B., J.Q., S.W.H., M.G.), University of Adelaide, SA 5064, Australia;Centre for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia (B.L., M.T.);School of BioSciences, University of Melbourne, Parkville, Vic 3010, Australia (A.A.T.J.); and Centre for Genomics and Systems Biology, New York University, New York 10003 (K.D.B.).
Sam W HendersonAustralian Centre for Plant Functional Genomics (B.L., J.Q., U.B., M.H., A.E., D.J., M.T., S.J.R.), School of Agriculture, Food, and Wine (B.L., C.B., J.Q., U.B., M.H., A.E., G.M.M., D.J., S.W.H., M.T., M.G., S.J.R.), and ARC Centre of Excellence in Plant Energy Biology (C.B., J.Q., S.W.H., M.G.), University of Adelaide, SA 5064, Australia;Centre for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia (B.L., M.T.);School of BioSciences, University of Melbourne, Parkville, Vic 3010, Australia (A.A.T.J.); and Centre for Genomics and Systems Biology, New York University, New York 10003 (K.D.B.).ORCID http://orcid.org/0000-0003-3019-1891
Mark TesterAustralian Centre for Plant Functional Genomics (B.L., J.Q., U.B., M.H., A.E., D.J., M.T., S.J.R.), School of Agriculture, Food, and Wine (B.L., C.B., J.Q., U.B., M.H., A.E., G.M.M., D.J., S.W.H., M.T., M.G., S.J.R.), and ARC Centre of Excellence in Plant Energy Biology (C.B., J.Q., S.W.H., M.G.), University of Adelaide, SA 5064, Australia;Centre for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia (B.L., M.T.);School of BioSciences, University of Melbourne, Parkville, Vic 3010, Australia (A.A.T.J.); and Centre for Genomics and Systems Biology, New York University, New York 10003 (K.D.B.) mark.tester@kaust.edu.sa matthew.gilliham@adelaide.edu.au.ORCID http://orcid.org/0000-0002-5085-8801
Mathew GillihamAustralian Centre for Plant Functional Genomics (B.L., J.Q., U.B., M.H., A.E., D.J., M.T., S.J.R.), School of Agriculture, Food, and Wine (B.L., C.B., J.Q., U.B., M.H., A.E., G.M.M., D.J., S.W.H., M.T., M.G., S.J.R.), and ARC Centre of Excellence in Plant Energy Biology (C.B., J.Q., S.W.H., M.G.), University of Adelaide, SA 5064, Australia;Centre for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia (B.L., M.T.);School of BioSciences, University of Melbourne, Parkville, Vic 3010, Australia (A.A.T.J.); and Centre for Genomics and Systems Biology, New York University, New York 10003 (K.D.B.) mark.tester@kaust.edu.sa matthew.gilliham@adelaide.edu.au.ORCID http://orcid.org/0000-0003-0666-3078
Stuart J RoyAustralian Centre for Plant Functional Genomics (B.L., J.Q., U.B., M.H., A.E., D.J., M.T., S.J.R.), School of Agriculture, Food, and Wine (B.L., C.B., J.Q., U.B., M.H., A.E., G.M.M., D.J., S.W.H., M.T., M.G., S.J.R.), and ARC Centre of Excellence in Plant Energy Biology (C.B., J.Q., S.W.H., M.G.), University of Adelaide, SA 5064, Australia;Centre for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia (B.L., M.T.);School of BioSciences, University of Melbourne, Parkville, Vic 3010, Australia (A.A.T.J.); and Centre for Genomics and Systems Biology, New York University, New York 10003 (K.D.B.).ORCID http://orcid.org/0000-0003-0411-9431
Australian Centre for Plant Functional Genomics · AUNew York University · USThe University of Melbourne · AU
Funding
No grant is acknowledged in the PubMed record.
Abstract
Under saline conditions, higher plants restrict the accumulation of chloride ions (Cl(-)) in the shoot by regulating their transfer from the root symplast into the xylem-associated apoplast. To identify molecular mechanisms underpinning this phenomenon, we undertook a transcriptional screen of salt stressed Arabidopsis (Arabidopsis thaliana) roots. Microarrays, quantitative RT-PCR, and promoter-GUS fusions identified a candidate gene involved in Cl(-) xylem loading from the Nitrate transporter 1/Peptide Transporter family (NPF2.4). This gene was highly expressed in the root stele compared to the cortex, and its expression decreased after exposure to NaCl or abscisic acid. NPF2.4 fused to fluorescent proteins, expressed either transiently or stably, was targeted to the plasma membrane. Electrophysiological analysis of NPF2.4 in Xenopus laevis oocytes suggested that NPF2.4 catalyzed passive Cl(-) efflux out of cells and was much less permeable to NO3(-). Shoot Cl(-) accumulation was decreased following NPF2.4 artificial microRNA knockdown, whereas it was increased by overexpression of NPF2.4. Taken together, these results suggest that NPF2.4 is involved in long-distance transport of Cl(-) in plants, playing a role in the loading and the regulation of Cl(-) loading into the xylem of Arabidopsis roots during salinity stress.
Indexed as
Abscisic AcidAnimalsArabidopsisArabidopsis ProteinsBiological TransportCell MembraneChloridesComputational BiologyDown-RegulationGene Expression Regulation, PlantGene Knockdown TechniquesGenes, PlantGenetic Association StudiesGlucuronidaseMembrane Transport ProteinsOocytesAbscisic AcidArabidopsis ProteinsChloridesGlucuronidaseMembrane Transport ProteinsSodium Chloride
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