Evidence map›Paper›PMID 26662579›Full record

ArticleMuscle & nerve2016

Forelimb muscle plasticity following unilateral cervical spinal cord injury.

Elisa J Gonzalez-Rothi, Gregory T Armstrong, Anthony J Cerreta, Garrett M Fitzpatrick, Paul J Reier, Michael A Lane, Andrew R Judge, David D Fuller

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Muscle & nerve, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Elisa J Gonzalez-RothiDepartment of Physical Therapy, College of Public Health and Health Professions, McKnight Brain Institute, University of Florida, P.O. Box 100154, 100 South Newell Drive, Gainesville, Florida, 32610, USA.
Gregory T ArmstrongDepartment of Physical Therapy, College of Public Health and Health Professions, McKnight Brain Institute, University of Florida, P.O. Box 100154, 100 South Newell Drive, Gainesville, Florida, 32610, USA.
Anthony J CerretaDepartment of Physical Therapy, College of Public Health and Health Professions, McKnight Brain Institute, University of Florida, P.O. Box 100154, 100 South Newell Drive, Gainesville, Florida, 32610, USA.
Garrett M FitzpatrickDepartment of Physical Therapy, College of Public Health and Health Professions, McKnight Brain Institute, University of Florida, P.O. Box 100154, 100 South Newell Drive, Gainesville, Florida, 32610, USA.
Paul J ReierDepartment of Neuroscience, College of Medicine, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
Michael A LaneDepartment of Neuroscience, College of Medicine, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
Andrew R JudgeDepartment of Physical Therapy, College of Public Health and Health Professions, McKnight Brain Institute, University of Florida, P.O. Box 100154, 100 South Newell Drive, Gainesville, Florida, 32610, USA.
David D FullerDepartment of Physical Therapy, College of Public Health and Health Professions, McKnight Brain Institute, University of Florida, P.O. Box 100154, 100 South Newell Drive, Gainesville, Florida, 32610, USA.
University of Florida · USUniversity of Florida Health Science Center · US

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
Rehabilitation Research Career Development ProgramK12HD055929 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BROWN, DAVID A · 2007 to 2021
$11.7M
Control of Breathing & Glycogen Storage DiseaseR01HD052682 · NICHD · UNIVERSITY OF FLORIDA · PI BYRNE, BARRY J, FULLER, DAVID D · 2007 to 2024
$6.4M
Training In Rehabilitation and Neuromuscular PlasticityT32HD043730 · NICHD · UNIVERSITY OF FLORIDA · PI DAVID D FULLER · 2003 to 2026
$5.3M
Modulation of Phrenic Motoneuron Plasticity after Cervical Spinal Cord InjuryR01NS080180 · NINDS · UNIVERSITY OF FLORIDA · PI FULLER, DAVID D · 2012 to 2016
$1.7M
NCATS NIH HHS UL1 TR001427NICHD NIH HHS 1R01-HD-052682NICHD NIH HHS K12 HD055929NICHD NIH HHS R01 HD052682NICHD NIH HHS T32 HD043730NINDS NIH HHS NS80180NINDS NIH HHS R01 NS080180
6 · The paper itself

Abstract

introductionMotor dysfunction and muscle atrophy are well documented in the lower extremity after spinal cord injury. However, the extent and time course of myoplastic changes in forelimb musculature is not clear.

methodsForelimb muscle morphology and fiber type were evaluated after high cervical hemilesion injury in rats.

resultsThere was significant atrophy of the ipsilateral extensor carpi radialis longus (ECRL) muscle at 2 weeks postinjury, which was subsequently reversed at 8 weeks postinjury. The triceps muscle showed minimal evidence of atrophy after spinal injury. No significant changes in fiber type were observed.

conclusionsThese findings indicate a robust capacity for spontaneous myoplasticity after C2 hemisection injury but highlight differential capacity for plasticity within the forelimb muscles.

Indexed as

Analysis of VarianceAnimalsCervical VertebraeDisease Models, AnimalFemaleForelimbFunctional LateralityMuscle, SkeletalSpinal Cord InjuriesTime Factorsatrophyforelimb musclemyoplasticityspinal cord injuryspontaneous recoveryupper extremity

Identifiers

PMID26662579
PMCPMC4733411
OpenAlexW2194965870

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.