ReviewInternational journal of hematology2016
Mechanisms of self-renewal in hematopoietic stem cells.
Review in International journal of hematology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Human Hematopoietic Stem Cells Enhance Maturational Differentiation of hiPSC-Derived Cardiomyocytes on Xeno-Free MatriClone-Plastic via EGFR/MAPK/ERK Signaling Pathway.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Exploring the contribution of Zfp521/ZNF521 on primary hematopoietic stem/progenitor cells and leukemia progression.Cell and tissue research · 2024Review
- Review
- Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity.Nature reviews. Molecular cell biology · 2023Review
- Review
- Review
- Isolation, Maintenance and Expansion of Adult Hematopoietic Stem/Progenitor Cells and Leukemic Stem Cells.Cancers · 2022Review
- Hematopoietic Stem Cell Factors: Their Functional Role in Self-Renewal and Clinical Aspects.Frontiers in cell and developmental biology · 2022Review
- ANP32B-mediated repression of p53 contributes to maintenance of normal and CML stem cells.Blood · 2021Article
- Molecular characterization of hematopoietic stem cells after in vitro amplification on biomimetic 3D PDMS cell culture scaffolds.Scientific reports · 2021Article
- Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells.The Journal of experimental medicine · 2021Article
- Differences and similarities between cancer and somatic stem cells: therapeutic implications.Stem cell research & therapy · 2020Review
- Regulation of Hematopoietic Stem Cell Fate and Malignancy.International journal of molecular sciences · 2020Review
- Acute and late effects of combined internal and external radiation exposures on the hematopoietic system.International journal of radiation biology · 2019Article
- [Key transcription factors in myeloid hematopoiesis].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2019Article
- Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis.Nature communications · 2019Article
- The nuclear receptor corepressor NCoR1 regulates hematopoiesis and leukemogenesis in vivo.Blood advances · 2019Article
- The mirn23a and mirn23b microrna clusters are necessary for proper hematopoietic progenitor cell production and differentiation.Experimental hematology · 2018Article
- NOS2 deficiency has no influence on the radiosensitivity of the hematopoietic system.Cell & bioscience · 2018Article
- Loss of quiescence and self-renewal capacity of hematopoietic stem cell in an in vitro leukemic niche.Experimental hematology & oncology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A large number of studies have shown that quiescence is essential for hematopoietic stem cells (HSCs) to maintain their number and function. Otherwise, HSCs are exhausted or damaged by various substances. We need to understand how the quiescent state is maintained in HSCs, how HSCs are driven into the cell cycle, and how HSCs return to the quiescent state. We also need to understand how cycling HSCs make the decision whether to self-renew. A number of molecules have been reported as candidate regulators of these events in HSCs. In this review, we focus on the HSC niche, the cytokine network, and associated transcription factors; and then discuss to what extent we can currently understand these critical issues in stem cell biology.
Indexed as
Identifiers
26662558What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.