Evidence map›Paper›PMID 26662508›Full record

ArticleEuropean journal of neurology2016

Gait phenotype from mild cognitive impairment to moderate dementia: results from the GOOD initiative.

G Allali, C Annweiler, H M Blumen, M L Callisaya, A-M De Cock, R W Kressig, V Srikanth, J-P Steinmetz, J Verghese, O Beauchet

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06857136 (The Role of the Glymphatic System Avaluated Thourgh mr Imaging in the Diagnosis and Management of NPH), which is not on this map. Cited by 75 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06857136 completednot on this mapstarted 2021, after this paper: background citation

The Role of the Glymphatic System Avaluated Thourgh mr Imaging in the Diagnosis and Management of NPH

TypeobservationalSponsorFondazione I.R.C.C.S. Istituto Neurologico Carlo BestaRan2021 to 2024Enrolled29ConditionsHydrocephalus, Normal Pressure Hydrocephalus
3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Gait in cerebral small vessel disease, pre-dementia, and dementia: A systematic review.International journal of stroke : official journal of the International Stroke Society · 2023
    Pooled it
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  5. Poor Gait Performance and Prediction of Dementia: Results From a Meta-Analysis.Journal of the American Medical Directors Association · 2016
    Pooled it
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  18. Longitudinal investigation of gait and Alzheimer's disease in adults with Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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  20. Review

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

G AllaliDepartment of Neurology, Division of Cognitive and Motor Aging, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA.
C AnnweilerDepartment of Neuroscience, Division of Geriatric Medicine, UPRES EA 4638, UNAM, Angers University Hospital, Angers, France.
H M BlumenDepartment of Neurology, Division of Cognitive and Motor Aging, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA.
M L CallisayaMenzies Institute of Medical Research, University of Tasmania, Tasmania, Australia.
A-M De CockDepartment of Geriatric Medicine, AZ ST Maarten Mechelen, Mechelen, Belgium.
R W KressigUniversity Center for Medicine of Aging, Felix Platter Hospital and University of Basel, Basel, Switzerland.
V SrikanthMenzies Institute of Medical Research, University of Tasmania, Tasmania, Australia.
J-P SteinmetzCentre for Memory and Mobility (CeM²), Luxembourg City, Luxembourg.
J VergheseDepartment of Neurology, Division of Cognitive and Motor Aging, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA.
O BeauchetDepartment of Neuroscience, Division of Geriatric Medicine, UPRES EA 4638, UNAM, Angers University Hospital, Angers, France.

Funding

Kerala-Einstein Study: Healthy lifestyle, vascular disease, and cognitive declineR01AG039330 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MATHURANATH, PAVAGADA S, VERGHESE, JOE · 2011 to 2023
$5.0M
Biological and neural mechanisms of fallsR01AG044007 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI VERGHESE, JOE · 2013 to 2017
$3.5M
Central Control of Mobility in AgingR01AG036921 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HOLTZER, ROEE · 2011 to 2015
$3.3M
NIA NIH HHS R01 AG036921NIA NIH HHS R01AG036921NIA NIH HHS R01 AG039330NIA NIH HHS R01 AG044007NIA NIH HHS R01AG044007-01A1
6 · The paper itself

Abstract

background and purposeThe differences in gait abnormalities from the earliest to the later stages of dementia and in the different subtypes of dementia have not been fully examined. This study aims to compare spatiotemporal gait parameters in cognitively healthy individuals, patients with amnestic mild cognitive impairment (MCI) and non-amnestic MCI, and patients with mild and moderate stages of Alzheimer's disease (AD) and non-Alzheimer's disease (non-AD).

methodsBased on a cross-sectional design, 1719 participants (77.4 ± 7.3 years, 53.9% female) were recruited from cohorts from seven countries participating in the Gait, Cognition and Decline (GOOD) initiative. Mean values and coefficients of variation of spatiotemporal gait parameters were measured during normal pace walking with the GAITRite system at all sites.

resultsPerformance of spatiotemporal gait parameters declined in parallel with the stage of cognitive decline from MCI status to moderate dementia. Gait parameters of patients with non-amnestic MCI were more disturbed compared to patients with amnestic MCI, and MCI subgroups performed better than demented patients. Patients with non-AD dementia had worse gait performance than those with AD dementia. This degradation of gait parameters was similar between mean values and coefficients of variation of spatiotemporal gait parameters in the earliest stages of cognitive decline, but different in the most advanced stages, especially in the non-AD subtypes.

conclusionsSpatiotemporal gait parameters were more disturbed in the advanced stages of dementia, and more affected in the non-AD dementias than in AD. These findings suggest that quantitative gait parameters could be used as a surrogate marker for improving the diagnosis of dementia.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseAmnesiaCognitive DysfunctionCross-Sectional StudiesDementiaFemaleGait Disorders, NeurologicHumansMalePhenotypeagingAlzheimer's diseasecohort studiesdementiagait disordersmild cognitive impairmentmotor controlquantitative gait parameters

Identifiers

PMID26662508
PMCPMC4769662

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.