Evidence map›Paper›PMID 26662362›Full record

ArticleNeurology and therapy2015

Patient Satisfaction with the New Interferon Beta-1b Autoinjector (BETACONNECT™).

Tjalf Ziemssen, Lauren Sylvester, Mark Rametta, Amy Perrin Ross

Open access · goldAbstract read
In one paragraph

Article in Neurology and therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Non-transdermal microneedles for advanced drug delivery.Advanced drug delivery reviews · 2020
    Pooled it
  2. Review
  3. Article
  4. Autoinjector - A smart device for emergency cum personal therapy.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2021
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Observational
  10. Review
  11. Observational
  12. Article
  13. Article
  14. Article
  15. Patient-Reported Disease-Modifying Therapy Adherence in the Clinic: A Reliable Metric?Multiple sclerosis journal - experimental, translational and clinical
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Tjalf ZiemssenDepartment of Neurology, Centre for Clinical Neurosciences, University Hospital Carl Gustav Carus at the Technical University of Dresden, Dresden, Germany. tjalf.ziemssen@uniklinikum-dresden.de.
Lauren SylvesterBayer HealthCare Pharmaceuticals, Whippany, NJ, USA.
Mark RamettaBayer HealthCare Pharmaceuticals, Whippany, NJ, USA.
Amy Perrin RossLoyola University Chicago, Maywood, IL, USA.
Bayer (United States) · USLoyola University Chicago · USUniversity Hospital Carl Gustav Carus · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMultiple sclerosis (MS) typically requires life-long management with disease-modifying therapies (DMTs). Many DMTs require regular self-injection, and can be associated with injection site reactions, pain, and needle/injection phobia-but these can be addressed by improvements in autoinjector design. The aim of this study was to investigate patient satisfaction and preference for BETACONNECT™ (Bayer Pharma AG), a novel interferon beta-1b autoinjector.

methodsPatients in Germany performing self-injections using BETACONNECT took part in the study. Data were collected through an online 15-min structured survey. Participants rated their experience with BETACONNECT on a 6-point scale and those satisfied with BETACONNECT were asked to describe the reason using a free-text box.

resultsOne-hundred and eighteen patients with MS completed the survey. Ninety percent preferred BETACONNECT to their previous injection method (only 4% previously used manual injections, so most had previously used other autoinjectors). Ninety-two percent were very confident/confident in their ability to perform an injection using BETACONNECT. The most common free-text responses to "Why are you satisfied with the BETACONNECT™ autoinjector?" were ease of use (46%), less irritation/pain at the injection site (33%), and smoother injections (24%). Features considered most useful were automated injections (98%), adjustable injection speed (98%), and adjustable injection depth (98%). Ninety-seven percent thought it was easy to know when an injection was complete and 95% agreed/strongly agreed it was easy to learn to use the autoinjector. Seventy-three percent agreed that the quietness and effortlessness of the BETACONNECT reduced their level of injection anxiety, 92% that its size and shape makes it easy to handle during injections, and 67% that it decreases injection site pain. Eighty percent of those using the reminder function thought they were less likely to miss an injection.

conclusionPatients with MS self-injecting interferon beta-1b expressed a high level of satisfaction and preference for BETACONNECT. Thus, BETACONNECT represents a valid option to improve patients' overall injection experience.

fundingBayer HealthCare Pharmaceuticals.

Indexed as

Beta-interferonsDisease-modifying therapiesElectronic autoinjectorPatient surveyRelapsing–remitting multiple sclerosis

Identifiers

PMID26662362
PMCPMC4685867
OpenAlexW1829416001

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.