ArticlePlant physiology2016
Phloem-Specific Methionine Recycling Fuels Polyamine Biosynthesis in a Sulfur-Dependent Manner and Promotes Flower and Seed Development.
Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 30 citations in OpenAlex.
- Methylthioadenosine-driven rewiring of sulfur assimilation lowers the methyl index and fertility in Arabidopsis.Journal of experimental botany · 2026Article
- Apoplastic metabolomics reveals sugars as mesophyll messengers regulating guard cell ion transport under red light.Nature plants · 2025Article
- Optimized LC-MS method for simultaneous polyamine profiling and ADC/ODC activity quantification and evidence that ADCs are indispensable for flower development in tomato.Frontiers in plant science · 2025Article
- The Effect of Ethephon on Ethylene and Chlorophyll inInternational journal of molecular sciences · 2024Article
- Novel SNP markers for flowering and seed quality traits in faba bean (Frontiers in plant science · 2024Article
- Exogenous spermidine improved drought tolerance inFrontiers in plant science · 2023Article
- Yang cycle enzyme DEP1: its moonlighting functions in PSI and ROS production during leaf senescence.Molecular horticulture · 2022Article
- Label-free quantitative proteomics of arbuscular mycorrhizalFrontiers in plant science · 2022Article
- Understanding In Vitro Tissue Culture-Induced Variation Phenomenon in Microspore System.International journal of molecular sciences · 2021Review
- Biologia futura: the role of polyamine in plant science.Biologia futura · 2020Review
- MiR319 mediated salt tolerance by ethylene.Plant biotechnology journal · 2019Article
- Symplasmic phloem unloading and radial post-phloem transport via vascular rays in tuberous roots of Manihot esculenta.Journal of experimental botany · 2019Article
- Boron Deficiency Effects on Sugar, Ionome, and Phytohormone Profiles of Vascular and Non-Vascular Leaf Tissues of Common Plantain (International journal of molecular sciences · 2019Article
- PROMIS, global analysis of PROtein-metabolite interactions using size separation inThe Journal of biological chemistry · 2018Article
- Polyamines in the life of Arabidopsis: profiling the expression of S-adenosylmethionine decarboxylase (SAMDC) gene family during its life cycle.BMC plant biology · 2017Article
- The relative contribution of genes operating in the S-methylmethionine cycle to methionine metabolism in Arabidopsis seeds.Plant cell reports · 2017Article
- Metabolic Investigation ofFrontiers in plant science · 2017Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Yang or Met Cycle is a series of reactions catalyzing the recycling of the sulfur (S) compound 5'-methylthioadenosine (MTA) to Met. MTA is produced as a by-product in ethylene, nicotianamine, and polyamine biosynthesis. Whether the Met Cycle preferentially fuels one of these pathways in a S-dependent manner remained unclear so far. We analyzed Arabidopsis (Arabidopsis thaliana) mutants with defects in the Met Cycle enzymes 5-METHYLTHIORIBOSE-1-PHOSPHATE-ISOMERASE1 (MTI1) and DEHYDRATASE-ENOLASE-PHOSPHATASE-COMPLEX1 (DEP1) under different S conditions and assayed the contribution of the Met Cycle to the regeneration of S for these pathways. Neither mti1 nor dep1 mutants could recycle MTA but showed S-dependent reproductive failure, which was accompanied by reduced levels of the polyamines putrescine, spermidine, and spermine in mutant inflorescences. Complementation experiments with external application of these three polyamines showed that only the triamine spermine could specifically rescue the S-dependent reproductive defects of the mutant plants. Furthermore, expressing gene-reporter fusions in Arabidopsis showed that MTI1 and DEP1 were mainly expressed in the vasculature of all plant parts. Phloem-specific reconstitution of Met Cycle activity in mti1 and dep1 mutant plants was sufficient to rescue their S-dependent mutant phenotypes. We conclude from these analyses that phloem-specific S recycling during periods of S starvation is essential for the biosynthesis of polyamines required for flowering and seed development.
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