ArticleEuropean radiology2016
HRCT features distinguishing pre-invasive from invasive pulmonary adenocarcinomas appearing as ground-glass nodules.
Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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46 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- [Advance in Diagnose and Treatment Strategies of Adenocarcinoma in Situ].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2017Pooled it
- ΔAverage of long and short axis diameter on non-contrast CT is associated with major pathological response to neoadjuvant immunotherapy in resectable non-small cell lung cancer.European radiology · 2026Article
- Improving the preoperative diagnosis of invasive lung adenocarcinoma by combining multiplanar volume rendering (MPVR)-based solid component measurement with pathological analysis.Quantitative imaging in medicine and surgery · 2026Article
- Preoperative CT-based artificial intelligence-derived quantitative parameters and imaging features for predicting the invasiveness of histologically confirmed subcentimeter adenocarcinomatous nodules: a two-center study.Quantitative imaging in medicine and surgery · 2025Article
- Lesion-vessel spatial relationship: a significant indicator for differentiation and evaluation of pulmonary ground-glass nodules.Quantitative imaging in medicine and surgery · 2025Article
- Significance of the Lesion-Pleura Relationship in Differentiating Peripheral Inflammatory Lesions and Lung Cancers.Journal of inflammation research · 2025Article
- Clinical and CT characteristics for predicting lymph node metastasis in patients with synchronous multiple primary lung adenocarcinoma.BMC medical imaging · 2024Article
- Using CT features of cystic airspace to predict lung adenocarcinoma invasiveness.Quantitative imaging in medicine and surgery · 2024Article
- The differential diagnosis of lung precursor glandular lesions, micro-invasive adenocarcinoma, and invasive adenocarcinoma using low dose spectral computed tomography perfusion imaging.Quantitative imaging in medicine and surgery · 2024Article
- Thin-slice computed tomography enables to classify pulmonary subsolid nodules into pre-invasive lesion/minimally invasive adenocarcinoma and invasive adenocarcinoma: a retrospective study.Scientific reports · 2023Article
- An integrated nomogram combined semantic-radiomic features to predict invasive pulmonary adenocarcinomas in subjects with persistent subsolid nodules.Quantitative imaging in medicine and surgery · 2023Article
- Analysis of the correlation between clinical and imaging features of malignant lung nodules and pathological types.Frontiers in surgery · 2023Article
- Differential diagnosis of benign and malignant patchy ground-glass opacity by thin-section computed tomography.BMC cancer · 2022Article
- Computed tomography-guided core needle biopsy for sub-centimeter pulmonary nodules.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2022Article
- Correlation between CT imaging characteristics and pathological diagnosis for subcentimeter pulmonary nodules.Thoracic cancer · 2022Article
- CT-Assisted Improvements in the Accuracy of the Intraoperative Frozen Section Examination of Ground-Glass Density Nodules.Computational and mathematical methods in medicine · 2022Article
- 3D deep learning versus the current methods for predicting tumor invasiveness of lung adenocarcinoma based on high-resolution computed tomography images.Frontiers in oncology · 2022Article
- A predictive model based on ground glass nodule featuresFrontiers in surgery · 2022Article
- Correlation Analysis of Computed Tomography Features and Pathological Types of Multifocal Ground-Glass Nodular Lung Adenocarcinoma.Computational and mathematical methods in medicine · 2022Article
- Implementation of artificial intelligence in the histological assessment of pulmonary subsolid nodules.Translational lung cancer research · 2021Article
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6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the high-resolution computed tomography (HRCT) features that distinguish lung adenocarcinomas in situ (AISs) and minimally invasive adenocarcinomas (MIAs) from invasive adenocarcinomas (IACs) appearing as ground-glass nodules (GGNs), and to select candidates for sublobar resection.
methodsTwo hundred and twenty-nine patients with 237 GGNs of less than 2 cm (139 AIS-MIA nodules and 98 IAC nodules) confirmed by surgery and pathology were retrospectively reviewed. The HRCT features of the AIS-MIAs and IACs were analysed and compared. Receiver operating characteristic (ROC) analyses were conducted to determine the cutoff values for the qualitative variables and their diagnostic performances.
resultsSignificant differences were found in the density, nodule and solid component diameters, CT values of the ground-glass and solid components, lobulated shape, spiculated margin, abnormal pulmonary vein and artery, air bronchogram, and pleural indentation of the GGNs between the two groups. Multivariate and ROC analyses revealed that larger diameter of nodules (≥12.2 mm) and solid components (≥6.7 mm), and higher CT values of the solid components (≥ -192 HU) in the GGNs with air bronchogram were significantly associated with IACs.
conclusionsHRCT can identify distinguishing morphological features between AIS-MIAs and IACs, and is helpful for selecting candidates for sublobar resection. KEY POINTS: • IACs appearing as GGNs were often ≥ 12.2 mm in diameter. • IACs were often ≥ 6.7 mm in solid component diameter. • The solid components of the IACs often exhibited ≥ -192 HU. • IACs exhibited air bronchogram more frequently than AIS-MIAs.
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